ArticleThe Journal of cell biology2006
TPX2 is required for postmitotic nuclear assembly in cell-free Xenopus laevis egg extracts.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- An Analysis Regarding the Association Between the Nuclear Pore Complex (NPC) and Hepatocellular Carcinoma (HCC).Journal of hepatocellular carcinoma · 2023Article
- Review
- HPV Infection Significantly Accelerates Glycogen Metabolism in Cervical Cells with Large Nuclei: Raman Microscopic Study with Subcellular Resolution.International journal of molecular sciences · 2020Article
- Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit.Cells · 2020Article
- Article
- Xenopus LAP2β protein knockdown affects location of lamin B and nucleoporins and has effect on assembly of cell nucleus and cell viability.Protoplasma · 2016Article
- Use of Xenopus cell-free extracts to study size regulation of subcellular structures.The International journal of developmental biology · 2016Review
- Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion.The Journal of cell biology · 2014Article
- Sizing and shaping the nucleus: mechanisms and significance.Current opinion in cell biology · 2014Review
- Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells.Journal of experimental botany · 2013Article
- Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2.Genes & cancer · 2012Article
- Article
- Embryonic and adult isoforms of XLAP2 form microdomains associated with chromatin and the nuclear envelope.Cell and tissue research · 2011Article
- The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown.The Plant cell · 2008Article
- Myosin-10 and actin filaments are essential for mitotic spindle function.The Journal of cell biology · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell division in many metazoa is accompanied by the disassembly of the nuclear envelope and the assembly of the mitotic spindle. These dramatic structural rearrangements are reversed after mitosis, when the mitotic spindle is dismantled and the nuclear envelope reassembles. The targeting protein for XKlp2 (TPX2) plays important roles in mitotic spindle assembly. We report that TPX2 depletion from nuclear assembly extracts prepared from Xenopus laevis eggs results in the formation of nuclei that are only about one fifth the size of control nuclei. TPX2-depleted nuclei assemble nuclear envelopes, nuclear pore complexes, and a lamina, and they perform nuclear-specific functions, including DNA replication. We show that TPX2 interacts with lamina-associated polypeptide 2 (LAP2), a protein known to be required for nuclear assembly in interphase extracts and in vitro. LAP2 localization is disrupted in TPX2-depleted nuclei, suggesting that the interaction between TPX2 and LAP2 is required for postmitotic nuclear reformation.
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