ArticleProceedings of the National Academy of Sciences of the United States of America2006
Multiple and time-scheduled in situ DNA delivery mediated by beta-cyclodextrin embedded in a polyelectrolyte multilayer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 223 citations in OpenAlex.
- Cyclodextrins in the antiviral therapy.Journal of drug delivery science and technology · 2021Review
- Computational Insights Into the Influence of Substitution Groups on the Inclusion Complexation of β-Cyclodextrin.Frontiers in chemistry · 2021Article
- Potential Implantable Nanofibrous Biomaterials Combined with Stem Cells for Subchondral Bone Regeneration.Materials (Basel, Switzerland) · 2020Article
- Programmable multi-DNA release from multilayered polyelectrolytes using gigahertz nano-electromechanical resonator.Journal of nanobiotechnology · 2019Article
- Biomaterial substrate modifications that influence cell-material interactions to prime cellular responses to nonviral gene delivery.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Complex Coacervation-Integrated Hybrid Nanoparticles Increasing Plasmid DNA Delivery Efficiency in Vivo.ACS applied materials & interfaces · 2016Article
- Controlling the surface-mediated release of DNA using 'mixed multilayers'.Bioengineering & translational medicine · 2016Article
- Growth factor-eluting technologies for bone tissue engineering.Drug delivery and translational research · 2016Review
- Polymer Multilayers that Promote the Rapid Release and Contact Transfer of DNA.Biomacromolecules · 2015Article
- A living thick nanofibrous implant bifunctionalized with active growth factor and stem cells for bone regeneration.International journal of nanomedicine · 2015Article
- Aggregation behaviour of amphiphilic cyclodextrins: the nucleation stage by atomistic molecular dynamics simulations.Beilstein journal of organic chemistry · 2015Article
- Cartilage oligomeric matrix protein gene multilayers inhibit osteogenic differentiation and promote chondrogenic differentiation of mesenchymal stem cells.International journal of molecular sciences · 2014Article
- Controllably local gene delivery mediated by polyelectrolyte multilayer films assembled from gene-loaded nanopolymersomes and hyaluronic acid.International journal of nanomedicine · 2014Article
- Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.Advanced drug delivery reviews · 2013Review
- Polymer multilayer tattooing for enhanced DNA vaccination.Nature materials · 2013Article
- Rapid release of plasmid DNA from surfaces coated with polyelectrolyte multilayers promoted by the application of electrochemical potentials.ACS applied materials & interfaces · 2012Article
- Article
- PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses.International journal of nanomedicine · 2012Article
- Biomedical Applications of Biodegradable Polymers.Journal of polymer science. Part B, Polymer physics · 2011Article
- Polyelectrolyte multilayers in tissue engineering.Tissue engineering. Part B, Reviews · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basic premise of gene therapy is that genes can be used to produce in situ therapeutic proteins. The controlled delivery of DNA complexes from biomaterials offers the potential to enhance gene transfer by maintaining an elevated concentration of DNA within the cellular microenvironment. Immobilization of the DNA to the substrate to which cells adhere maintains the DNA in the cell microenvironment for subsequent cellular internalization. Here, layer-by-layer (LBL) films made from poly(L-glutamic acid) (PLGA) and poly(L-lysine) (PLL) containing DNA were built in the presence of charged cyclodextrins. The biological activities of these polyelectrolyte films were tested by means of induced production of a specific protein in the nucleus or in the cytoplasm by cells in contact with the films. This type of coating offers the possibility for either simultaneous or sequential interfacial delivery of different DNA molecules aimed at cell transfection. These results open the route to numerous potential applications in patch vaccination, for example.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.