ArticleBMC genomics2006
The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 124 citations in OpenAlex.
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- N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling.Chembiochem : a European journal of chemical biology · 2022Article
- Neisseria genes required for persistence identified via in vivo screening of a transposon mutant library.PLoS pathogens · 2022Article
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- Modelling evolutionary pathways for commensalism and hypervirulence inMicrobial genomics · 2021Article
- Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis.PLoS pathogens · 2021Article
- Caerin 1 Antimicrobial Peptides That Inhibit HIV andAntibiotics (Basel, Switzerland) · 2020Article
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- Complete genome and methylome analysis of Neisseria meningitidis associated with increased serogroup Y disease.Scientific reports · 2020Article
- Vital Members in the More Dysbiotic Oropharyngeal Microbiotas in H7N9-Infected Patients.Frontiers in medicine · 2020Article
- Atypical, Yet Not Infrequent, Infections withPathogens (Basel, Switzerland) · 2019Review
- Genetic determinants of genus-level glycan diversity in a bacterial protein glycosylation system.PLoS genetics · 2019Article
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- Development and Assessment of a Diagnostic DNA Oligonucleotide Microarray for Detection and Typing of Meningitis-Associated Bacterial Species.High-throughput · 2018Article
- Characterization of capsule genes in non-pathogenic Neisseria species.Microbial genomics · 2018Article
12 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
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Abstract
backgroundNeisseria meningitidis causes the life-threatening diseases meningococcal meningitis and meningococcal septicemia. Neisseria gonorrhoeae is closely related to the meningococcus, but is the cause of the very different infection, gonorrhea. A number of genes have been implicated in the virulence of these related yet distinct pathogens, but the genes that define and differentiate the species and their behaviours have not been established. Further, a related species, Neisseria lactamica is not associated with either type of infection in normally healthy people, and lives as a harmless commensal. We have determined which of the genes so far identified in the genome sequences of the pathogens are also present in this non-pathogenic related species.
resultsThirteen unrelated strains of N. lactamica were investigated using comparative genome hybridization to the pan-Neisseria microarray-v2, which contains 2845 unique gene probes. The presence of 127 'virulence genes' was specifically addressed; of these 85 are present in N. lactamica. Of the remaining 42 'virulence genes' only 11 are present in all four of the sequenced pathogenic Neisseria.
conclusionAssessment of the complete dataset revealed that the vast majority of genes present in the pathogens are also present in N. lactamica. Of the 1,473 probes to genes shared by all four pathogenic genome sequences, 1,373 hybridize to N. lactamica. These shared genes cannot include genes that are necessary and sufficient for the virulence of the pathogens, since N. lactamica does not share this behaviour. This provides an essential context for the interpretation of gene complement studies of the pathogens.
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