ArticleNeurochemical research2006
Glial activation and segmental upregulation of interleukin-1beta (IL-1beta) in the rat spinal cord after surgical incision.
Article in Neurochemical research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Incision-triggered neuroimmune remodeling of nociceptor ion channels: from postoperative inflammation to pain chronification.Frontiers in immunology · 2026Review
- Electroacupuncture relieves hyperalgesia by regulating neuronal-glial interaction and glutamate transporters of spinal dorsal horns in rats with acute incisional neck pain.Frontiers in neuroscience · 2022Article
- Repeated Morphine Prolongs Postoperative Pain in Male Rats.Anesthesia and analgesia · 2019Article
- Spinal Interleukin-1β Inhibits Astrocyte Cytochrome P450c17 Expression Which Controls the Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.Frontiers in molecular neuroscience · 2019Article
- Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats.Scientific reports · 2017Article
- Article
- TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms.Molecular pain · 2014Article
- Comparison of expression of inflammatory cytokines in the spinal cord between young adult and aged beagle dogs.Cellular and molecular neurobiology · 2013Article
- Gene expression in skin, muscle, and dorsal root ganglion after plantar incision in the rat.Anesthesiology · 2012Article
- Targeting astrocyte signaling for chronic pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2010Review
- Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming.The journal of pain · 2010Article
- Caspase-1 modulates incisional sensitization and inflammation.Anesthesiology · 2010Article
- Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.Brain, behavior, and immunity · 2008Article
- Brain derived neurotrophic factor (BDNF) contributes to the pain hypersensitivity following surgical incision in the rats.Molecular pain · 2008Article
- Comparison of ionized calcium-binding adapter molecule 1 immunoreactivity of the hippocampal dentate gyrus and CA1 region in adult and aged dogs.Neurochemical research · 2008Article
- Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway.Neuron glia biology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the expression patterns of glial cells and interleukin-1beta (IL-1beta) in the rat spinal cord after a surgical incision, which is closely related with clinical postoperative pain. Microglia and astrocytes became activated in the spinal cord following incision. Real-time polymerase chain reaction (PCR) and immunohistochemisty showed that IL-1beta mRNA and protein level in the spinal cord was transiently upregulated after surgical incision. The increased IL-1beta-immunoreactivity (IR) was mainly localized in neurons but not the activated microglia or astrocytes. Although obvious increase in IL-1beta-IR could be observed in the lumbar segments of the spinal cord ipsilateral to a hind paw incision, significant upregulation of IL-1beta was not detected in the lumbar segments following thoracic incision. The present study indicated that surgical incision could induce glial activation and segmental upregulation of IL-1beta in the spinal cord. The activated glial cells and upregulated IL-1beta, in turn, may be involved in the incision-induced pain hypersensitivity.
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