ArticleJournal of molecular histology2005
Cigarette smoke affects apoptosis in rat tongue mucosa: role of bcl-2 gene family.
Article in Journal of molecular histology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Genomic Instability in Peripheral Blood and Buccal Mucosal Cells of Marijuana Smokers: The Impact of Tobacco Smoke.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- miR-296-3p Negatively Regulated by Nicotine Stimulates Cytoplasmic Translocation of c-Myc via MK2 to Suppress Chemotherapy Resistance.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Article
- Nicotine increases the resistance of lung cancer cells to cisplatin through enhancing Bcl-2 stability.British journal of cancer · 2014Article
- Cytogenetic biomonitoring of oral mucosa cells of crack cocaine users.Environmental science and pollution research international · 2014Article
- The association between smoking and ectopic pregnancy: why nicotine is BAD for your fallopian tube.PloS one · 2014Article
- Apoptosis status and proliferative activity in mucopolysaccharidosis type I mice tongue mucosa cells.Dental research journal · 2012Article
- Alkylation-induced genotoxicity as a predictor of DNA repair deficiency following experimental oral carcinogenesis.Journal of molecular histology · 2012Article
- Cytogenetic biomonitoring in oral mucosa cells following dental X-ray.Dento maxillo facial radiology · 2012Review
- Impaired somatosensation in tongue mucosa of smokers.Clinical oral investigations · 2012Article
- Sensitization of epithelial growth factor receptors by nicotine exposure to promote breast cancer cell growth.Breast cancer research : BCR · 2011Article
- Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation.Journal of cellular biochemistry · 2010Article
- Cytogenetic biomonitoring of oral mucosa cells from adults exposed to dental X-rays.Radiation medicine · 2008Article
- Expression of placental glutathione S-transferase in rat tongue mucosa exposed to cigarette smoke.Journal of molecular histology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While it has been clearly demonstrated that smoking is the most significant exogenous factor involved in oral carcinogenesis, little is known about the global molecular and cellular changes that occur prior to the appearance of clinically detectable symptoms. Thus, the aim of this study was to investigate the expressivity of bcl-2, bax and PCNA in the rat tongue mucosa exposed to cigarette smoke by means of immunohistochemistry. A total of twelve male Wistar rats were distributed into 2 groups: negative control and experimental group exposed to cigarette smoke during 75 days. After experimental period, no histopathological changes in the tongue mucosa were detected in the negative control and the experimental group. On the other hand, an overexpression of bcl-2 was detected (p < 0.01) throughout all layers of the epithelium, whereas bax did not show significant differences (p > 0.05). Also, the labeling index for bcl-2 and bax showed an increase 75 days after cigarette exposure (p < 0.01). PCNA-labeling index did not show remarkable changes between groups. Taken together, our results show that bcl-2 is overexpressed in the rat tongue keratinocytes after cigarette smoke exposure.
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