ReviewPLoS genetics2006
The jewels of our genome: the search for the genomic changes underlying the evolutionarily unique capacities of the human brain.
Review in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Association of human-specific expanded short tandem repeats with neuron-specific regulatory features.Science advances · 2025Article
- A novel integrated extraction protocol for multi-omic studies in heavily degraded samples.Scientific reports · 2024Article
- Time to consider animal data governance: perspectives from neuroscience.Frontiers in neuroinformatics · 2023Article
- Genomic approaches to trace the history of human brain evolution with an emerging opportunity for transposon profiling of ancient humans.Mobile DNA · 2021Review
- Genetic Mechanisms Underlying Cortical Evolution in Mammals.Frontiers in cell and developmental biology · 2021Review
- An Easy-to-Implement Hierarchical Standardization for Variable Selection under Strong Heredity Constraint.Journal of statistical theory and practice · 2020Article
- Studying human and nonhuman primate evolutionary biology with powerful in vitro and in vivo functional genomics tools.Evolutionary anthropology · 2020Review
- Paired involvement of human-specific Olduvai domains and NOTCH2NL genes in human brain evolution.Human genetics · 2019Article
- Human evolution: the non-coding revolution.BMC biology · 2017Review
- Mice engrafted with human hematopoietic stem cells support a human myeloid cell inflammatory response in vivo.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2016Article
- Can a few non-coding mutations make a human brain?BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- The Immune Syntax Revisited: Opening New Windows on Language Evolution.Frontiers in molecular neuroscience · 2015Article
- Cognitive-behavioral phenotypes of Williams syndrome are associated with genetic variation in the GTF2I gene, in a healthy population.BMC neuroscience · 2014Article
- The case for DUF1220 domain dosage as a primary contributor to anthropoid brain expansion.Frontiers in human neuroscience · 2014Article
- Primate genome architecture influences structural variation mechanisms and functional consequences.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- No effect of genome-wide copy number variation on measures of intelligence in a New Zealand birth cohort.PloS one · 2013Article
- Evolution of genetic and genomic features unique to the human lineage.Nature reviews. Genetics · 2012Review
- Human brain evolution: from gene discovery to phenotype discovery.Proceedings of the National Academy of Sciences of the United States of America · 2012Review
- Exploring the role of copy number variants in human adaptation.Trends in genetics : TIG · 2012Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The recent publication of the initial sequence and analysis of the chimp genome allows us, for the first time, to compare our genome with that of our closest living evolutionary relative. With more primate genome sequences being pursued, and with other genome-wide, cross-species comparative techniques emerging, we are entering an era in which we will be able to carry out genomic comparisons of unprecedented scope and detail. These studies should yield a bounty of new insights about the genes and genomic features that are unique to our species as well as those that are unique to other primate lineages, and may begin to causally link some of these to lineage-specific phenotypic characteristics. The most intriguing potential of these new approaches will be in the area of evolutionary neurogenomics and in the possibility that the key human lineage-specific (HLS) genomic changes that underlie the evolution of the human brain will be identified. Such new knowledge should provide fresh insights into neuronal development and higher cognitive function and dysfunction, and may possibly uncover biological mechanisms for information storage, analysis, and retrieval never previously seen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.