ArticlePLoS pathogens2006
Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells.
Article in PLoS pathogens, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus-induced demyelination.Brain pathology (Zurich, Switzerland) · 2021Article
- Persistence and Sexual Transmission of Filoviruses.Viruses · 2018Review
- The role of MHC class Ib-restricted T cells during infection.Immunogenetics · 2016Review
- NFAT2 Regulates Generation of Innate-Like CD8Frontiers in immunology · 2016Article
- β2-microglobulin induces epithelial-mesenchymal transition in human renal proximal tubule epithelial cells in vitro.BMC nephrology · 2015Article
- The murine gammaherpesvirus immediate-early Rta synergizes with IRF4, targeting expression of the viral M1 superantigen to plasma cells.PLoS pathogens · 2014Article
- CD8α dendritic cells drive establishment of HSV-1 latency.PloS one · 2014Article
- An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- The genus Xenopus as a multispecies model for evolutionary and comparative immunobiology of the 21st century.Developmental and comparative immunology · 2011Review
- Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity.Current opinion in immunology · 2011Review
- NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency.Journal of virology · 2009Article
- A single CD8+ T cell epitope sets the long-term latent load of a murid herpesvirus.PLoS pathogens · 2008Article
- An MHC class Ib-restricted CD8 T cell response confers antiviral immunity.The Journal of experimental medicine · 2008Article
- A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology.The Journal of experimental medicine · 2008Article
- In vivo veritas: pathogenesis of infection as it actually happens.Nature immunology · 2007Review
- Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk.European journal of immunology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Control of virus infection is mediated in part by major histocompatibility complex (MHC) Class Ia presentation of viral peptides to conventional CD8 T cells. Although important, the absolute requirement for MHC Class Ia-dependent CD8 T cells for control of chronic virus infection has not been formally demonstrated. We show here that mice lacking MHC Class Ia molecules (K(b-/-)xD(b-/-) mice) effectively control chronic gamma-herpesvirus 68 (gammaHV68) infection via a robust expansion of beta2-microglobulin (beta2-m)-dependent, but CD1d-independent, unconventional CD8 T cells. These unconventional CD8 T cells expressed: (1) CD8alphabeta and CD3, (2) cell surface molecules associated with conventional effector/memory CD8 T cells, (3) TCRalphabeta with a significant Vbeta4, Vbeta3, and Vbeta10 bias, and (4) the key effector cytokine interferon-gamma (IFNgamma). Unconventional CD8 T cells utilized a diverse TCR repertoire, and CDR3 analysis suggests that some of that repertoire may be utilized even in the presence of conventional CD8 T cells. This is the first demonstration to our knowledge that beta2-m-dependent, but Class Ia-independent, unconventional CD8 T cells can efficiently control chronic virus infection, implicating a role for beta2-n-dependent non-classical MHC molecules in control of chronic viral infection. We speculate that similar unconventional CD8 T cells may be able to control of other chronic viral infections, especially when viruses evade immunity by inhibiting generation of Class Ia-restricted T cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.