ArticleAmerican journal of human genetics1991
A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates.
Article in American journal of human genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- High-resolution autosomal radiation hybrid maps of the pig genome and their contribution to the genome sequence assembly.BMC genomics · 2012Article
- Article
- The alpha-fetoprotein enhancer region activates the albumin and alpha-fetoprotein promoters during liver development.Developmental biology · 2009Article
- The map problem: a comparison of genetic and sequence-based physical maps.American journal of human genetics · 2002Article
- Evidence for heterogeneity in recombination in the human pseudoautosomal region: high resolution analysis by sperm typing and radiation-hybrid mapping.American journal of human genetics · 2000Article
- Evidence for effective suppression of recombination in the chromosome 17q21 segment spanning RNU2-BRCA1.American journal of human genetics · 1999Article
- Individual variation in recombination among human males.American journal of human genetics · 1996Article
- The extent, mechanism, and consequences of genetic variation, for recombination rate.American journal of human genetics · 1996Article
- Linkage between vitamin D-binding protein and alpha-fetoprotein in the mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Genetic mapping of the dentinogenesis imperfecta type II locus.American journal of human genetics · 1995Article
- Linkage disequilibrium patterns vary with chromosomal location: a case study from the von Willebrand factor region.American journal of human genetics · 1994Article
- A primary linkage map of the porcine genome reveals a low rate of genetic recombination.Genetics · 1994Article
- Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.American journal of human genetics · 1994Article
- The human skeletal muscle adenine nucleotide translocator gene maps to chromosome 4q35 in the region of the facioscapulohumeral muscular dystrophy locus.Human genetics · 1993Article
- Presence of telomeric and subtelomeric sequences at the fusion points of ring chromosomes indicates that the ring syndrome is caused by ring instability.Human genetics · 1993Article
- A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.American journal of human genetics · 1993Article
- Reevaluation of the chromosome 4q candidate region for early onset periodontitis.Human genetics · 1993Article
- Ordering genes: controlling the decision-error probabilities.American journal of human genetics · 1993Article
- Linkage analysis of schizophrenia with five dopamine receptor genes in nine pedigrees.American journal of human genetics · 1993Article
- Universal mapping probes and the origin of human chromosome 3.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Utilizing the CEPH reference panel and genotypic data for 53 markers, we have constructed a 20-locus multipoint genetic map of human chromosome 4. New RFLPs are reported for four loci. The map integrates a high-resolution genetic map of 4p16 into a continuous map extending to 4q31 and an unlinked cluster of three loci at 4q35. The 20 linked markers form a continuous linkage group of 152 cM in males and 202 cM in females. Likely genetic locations are provided for 25 polymorphic anonymous sequences and 28 gene-specific RFLPs. The map was constructed employing the LINKAGE and CRIMAP computational methodologies to build the multipoint map via a stepwise algorithm. A detailed 10-point map of the 4p16 region constructed from the CEPH panel provides evidence for heterogeneity in the linkage maps constructed from families segregating for Huntington disease (HD). It additionally provides evidence for position-specific recombination frequencies in the telomeric region of 4p.
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1673289PMC1683054What OpenQuestion holds
Registered trials
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