ArticleJournal of computational neuroscience2006
The temporal structure of transient ON/OFF ganglion cell responses and its relation to intra-retinal processing.
Article in Journal of computational neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- The mechanism of human color vision and potential implanted devices for artificial color vision.Frontiers in neuroscience · 2024Review
- Temporal properties of dual-peak responses of mouse retinal ganglion cells and effects of inhibitory pathways.Cognitive neurodynamics · 2016Article
- Coding Properties of Mouse Retinal Ganglion Cells with Dual-Peak Patterns with Respect to Stimulus Intervals.Frontiers in computational neuroscience · 2016Article
- Response dynamics of bullfrog ON-OFF RGCs to different stimulus durations.Journal of computational neuroscience · 2014Article
- Novel flicker-sensitive visual circuit neurons inhibited by stationary patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Identifying cell class specific losses from serially generated electroretinogram components.BioMed research international · 2013Article
- High speed coding for velocity by archerfish retinal ganglion cells.BMC neuroscience · 2012Article
- A retinal circuit model accounting for wide-field amacrine cells.Cognitive neurodynamics · 2009Article
- Throwing a glance at the neural code: rapid information transmission in the visual system.HFSP journal · 2009Article
- Modeling convergent ON and OFF pathways in the early visual system.Biological cybernetics · 2008Review
- Effects of fixational eye movements on retinal ganglion cell responses: a modelling study.Frontiers in computational neuroscience · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A subpopulation of transient ON/OFF ganglion cells in the turtle retina transmits changes in stimulus intensity as series of distinct spike events. The temporal structure of these event sequences depends systematically on the stimulus and thus carries information about the preceding intensity change. To study the spike events' intra-retinal origins, we performed extracellular ganglion cell recordings and simultaneous intracellular recordings from horizontal and amacrine cells. Based on these data, we developed a computational retina model, reproducing spike event patterns with realistic intensity dependence under various experimental conditions. The model's main features are negative feedback from sustained amacrine onto bipolar cells, and a two-step cascade of ganglion cell suppression via a slow and a fast transient amacrine cell. Pharmacologically blocking glycinergic transmission results in disappearance of the spike event sequence, an effect predicted by the model if a single connection, namely suppression of the fast by the slow transient amacrine cell, is weakened. We suggest that the slow transient amacrine cell is glycinergic, whereas the other types release GABA. Thus, the interplay of amacrine cell mediated inhibition is likely to induce distinct temporal structure in ganglion cell responses, forming the basis for a temporal code.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.