ReviewVirus genes2006
Inhibition of viruses by RNA interference.
Review in Virus genes, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- An asymptomatic geminivirus activates autophagy and enhances plant defenses against diverse pathogens.Stress biology · 2024Article
- Optimal delivery of RNA interference by viral vectors for cancer therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Review
- Coinfection and Interference Phenomena Are the Results of Multiple Thermodynamic Competitive Interactions.Microorganisms · 2021Article
- Suppression of Rice Stripe Virus Replication in Laodelphax striatellus Using Vector Insect-Derived Double-Stranded RNAs.The plant pathology journal · 2020Article
- A Glimpse of Nucleo-Cytoplasmic Large DNA Virus Biodiversity through the Eukaryotic Genomics Window.Viruses · 2017Article
- Insight into alternative approaches for control of avian influenza in poultry, with emphasis on highly pathogenic H5N1.Viruses · 2012Review
- Physiopathology of idiopathic nephrotic syndrome: lessons from glucocorticoids and epigenetic perspectives.Pediatric nephrology (Berlin, Germany) · 2012Review
- Small interfering RNA targeting for infected-cell polypeptide 4 inhibits herpes simplex virus type 1 replication in retinal pigment epithelial cells.Clinical & experimental ophthalmology · 2012Article
- Small molecule inhibition of RISC loading.ACS chemical biology · 2012Article
- SiRNA inhibits replication of Langat virus, a member of the tick-borne encephalitis virus complex in organotypic rat brain slices.PloS one · 2012Article
- Immunostimulatory motifs enhance antiviral siRNAs targeting highly pathogenic avian influenza H5N1.PloS one · 2011Article
- Toward a durable anti-HIV gene therapy based on RNA interference.Annals of the New York Academy of Sciences · 2009Review
- Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts.PloS one · 2009Article
- A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery.Biotechnology and bioengineering · 2009Article
- RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response.Journal of virology · 2008Article
- Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect.Nucleic acids research · 2008Article
- Interaction with host SGS3 is required for suppression of RNA silencing by tomato yellow leaf curl virus V2 protein.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Silencing of African horse sickness virus VP7 protein expression in cultured cells by RNA interference.Virus genes · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA-mediated interference (RNAi) is a recently discovered process by which dsRNA is able to silence specific gene functions. Although initially described in plants, nematodes and Drosophila, the process is currently considered to be an evolutionarily conserved process that is present in the entire eukaryotic kingdom in which its original function was as a defense mechanism against viruses and foreign nucleic acids. Similarly to the silencing of genes by RNAi, viral functions can be also silenced by the same mechanism, through the introduction of specific dsRNA molecules into cells, where they are targeted to essential genes or directly to the viral genome in case RNA viruses, thus arresting viral replication. Since the pioneering work of Elbashir and coworkers, who identified RNAi activity in mammalian cells, many publications have described the inhibition of viruses belonging to most if not all viral families, by targeting and silencing diverse viral genes as well as cell genes that are essential for virus replication. Moreover, virus expression vectors were developed and used as vehicles with which to deliver siRNAs into cells. This review will describe the use of RNAi to inhibit virus replication directly, as well as through the silencing of the appropriate cell functions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.