Evidence map›Paper›PMID 16731602›Full record

ArticleJournal of clinical pathology2006

MMP-2 but not MMP-9 associated with COX-2 and survival in gastric cancer.

J Mrena, J-P Wiksten, S Nordling, A Kokkola, A Ristimäki, C Haglund

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Assessment of the correlation between oxidative stress and expression ofArchives of medical sciences. Atherosclerotic diseases · 2021
    Article
  7. Targeting Lipid Peroxidation for Cancer Treatment.Molecules (Basel, Switzerland) · 2020
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  8. Role of extra cellular proteins in gastric cancer progression and metastasis: an update.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. MMP-2 and DcR3 expression in esophageal cancer tissue and correlation with patient survival.International journal of clinical and experimental medicine · 2013
    Article
  15. Article
  16. VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue.Medical science monitor : international medical journal of experimental and clinical research · 2012
    Article
  17. Article
  18. Article
  19. Article
  20. COX-2 is associated with proliferation and apoptosis markers and serves as an independent prognostic factor in gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

J MrenaDepartment of Surgery, Helsinki University Central Hospital, Helsinki, Finland.
J-P Wiksten
S Nordling
A Kokkola
A Ristimäki
C Haglund
Helsinki University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimMatrix metalloproteinases (MMPs) MMP-2 and MMP-9 can degrade type IV collagen of extracellular matrix and basal membranes. As cyclo-oxygenase-2 (COX-2) has been shown to activate MMPs, creating one of the COX-2-promoted pathways of tumour growth and metastasis, the prognostic role of MMP-2 and MMP-9 in gastric cancer was assessed and their association with COX-2 expression was evaluated. MATERIALS AND

methodsSamples were collected from 342 consecutive patients operated on for gastric cancer, of which 315 were acceptable for MMP-2, MMP-9 and COX-2 immunohistochemistry. Specimens were stained with specific antibodies, evaluated and categorised by two interpreters, and then correlated with clinical data and survival.

resultsEpithelial MMP-2 immunoreactivity was associated with male sex, high stage, advanced penetration depth, non-curative surgery, high COX-2 expression and poor survival. Stromal MMP-2 expression correlated with high stage, intestinal type and non-curative surgery whereas MMP-9 correlated only with intestinal type. Stage, intent of surgery and COX-2 were independent prognostic factors.

conclusionsEpithelial MMP-2 expression in gastric cancer is associated with aggressive forms, COX-2 and poor survival, although MMP-2 was not an independent prognostic factor. In gastric cancer tumour growth is apparently induced by COX-2, and invasion is mediated by MMP-2.

Indexed as

AdenocarcinomaAgedAge DistributionBiomarkers, TumorCyclooxygenase 2FemaleHumansLymphatic MetastasisMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Middle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisStomach NeoplasmsBiomarkers, TumorCyclooxygenase 2Matrix Metalloproteinase 2Matrix Metalloproteinase 9

Identifiers

PMID16731602
PMCPMC1860392
OpenAlexW2013946320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.