Evidence map›Paper›PMID 1673105›Full record

ArticleGenetics1991

Identification and applications of repetitive probes for gene mapping in the mouse.

L D Siracusa, N A Jenkins, N G Copeland

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 92 citations in OpenAlex.

  1. Article
  2. Isolation of candidate hybrid sterility 1 genes by cDNA selection in a 1.1 megabase pair region on mouse chromosome 17.Mammalian genome : official journal of the International Mammalian Genome Society · 1997
    Article
  3. A new mouse mutation causing male sterility and histoincompatibility.Mammalian genome : official journal of the International Mammalian Genome Society · 1996
    Article
  4. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.Proceedings of the National Academy of Sciences of the United States of America · 1996
    Article
  5. Mapping the mouse genome: current status and future prospects.Proceedings of the National Academy of Sciences of the United States of America · 1995
    Review
  6. Homologs of genes and anonymous loci on human chromosome 13 map to mouse chromosomes 8 and 14.Mammalian genome : official journal of the International Mammalian Genome Society · 1995
    Article
  7. Article
  8. The stumbler mutation maps to proximal mouse chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 1994
    Article
  9. Identification and genetic mapping of 151 dispersed members of 16 ribosomal protein multigene families in the mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 1994
    Article
  10. Mapping of mouse intracisternal A-particle proviral markers in an interspecific backcross.Mammalian genome : official journal of the International Mammalian Genome Society · 1994
    Article
  11. Article
  12. Article
  13. Identification and genetic mapping of the murine gene and 20 related sequences encoding chromosomal protein HMG-17.Mammalian genome : official journal of the International Mammalian Genome Society · 1993
    Article
  14. Article
  15. Article
  16. Multilocus markers for mouse genome analysis: PCR amplification based on single primers of arbitrary nucleotide sequence.Mammalian genome : official journal of the International Mammalian Genome Society · 1992
    Article
  17. Mapping of the mouse ornithine decarboxylase-related sequence family.Mammalian genome : official journal of the International Mammalian Genome Society · 1992
    Article
  18. A set of anonymous DNA clones as markers for mouse gene mapping.Mammalian genome : official journal of the International Mammalian Genome Society · 1992
    Article
  19. Genetic mapping of the murine gene and 14 related sequences encoding chromosomal protein HMG-14.Mammalian genome : official journal of the International Mammalian Genome Society · 1992
    Article
  20. Fine-structure mapping of the complex locus Odc-rs5 relative to Igk and distal loci.Mammalian genome : official journal of the International Mammalian Genome Society · 1992
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

L D SiracusaNCI-Frederick Cancer Research and Development Center, Mammalian Genetics Laboratory, Maryland 21702.
N A Jenkins
N G Copeland
Cancer Research Center · US

Funding

CLONING OF THE AGOUTI LOCUS IN THE MOUSEF32GM012721 · NIGMS · NATIONAL CANCER INSTITUTE-FREDERICK · PI SIRACUSA, LINDA D · 1988 to 1990
–
PROVIDE BASIC CANCER RESEARCHN01CO074101 · CO · ADVANCED BIOSCIENCE LABORATORIES, INC. · PI VANDE WOUDE, GEORGE F · 1987 to 1994
–
NCI NIH HHS N01-CO-74101NIGMS NIH HHS GM12721-01
6 · The paper itself

Abstract

Interspecific mouse hybrids that are viable and fertile provide a wealth of genetic variation that is useful for gene mapping. We are using this genetic variation to develop multilocus linkage maps of the mouse genome. As an outgrowth of this work, we have identified three repetitive probes that collectively identify 28 loci dispersed on 16 of the 19 mouse autosomes and the X chromosome. These loci establish a skeleton linkage map that can be used to detect linkage over much of the mouse genome. The molecular probes are derived from the mouse mammary tumor virus envelope gene, the ornithine decarboxylase gene, and the triose phosphate isomerase gene. The ability to scan the mouse genome quickly and efficiently in an interspecific cross using these three repetitive probes makes this system a powerful tool for identifying the chromosomal location of mutations that have yet to be cloned, mapping multigenic traits, and identifying recessive protooncogene loci associated with murine neoplastic disease. Ultimately, interspecific hybrids in conjunction with repetitive and single-copy probes will provide a rapid means to access virtually any gene of interest in the mouse genome at the molecular level.

Indexed as

DNA ProbesAnimalsBlotting, SouthernChromosome MappingCrosses, GeneticDNAGenes, RecessiveGenetic LinkageGenetic VariationMammary Tumor Virus, MouseMiceMice, Inbred C57BLMultigene FamilyMutationNeoplasms, ExperimentalOrnithine DecarboxylaseDNADNA ProbesOrnithine DecarboxylaseTriose-Phosphate Isomerase

Identifiers

PMID1673105
PMCPMC1204302
OpenAlexW1941767432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.