ArticleFEBS letters2006
Stretch-grown axons retain the ability to transmit active electrical signals.
Article in FEBS letters, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed.
- Glutamate signaling and transport around nodes of Ranvier and internodal myelin regions.Histology and histopathology · 2026Review
- Review
- The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023Review
- Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier.Acta neuropathologica · 2022Article
- Development of a Three-Dimensional Nerve Stretch Growth Device towards an Implantable Neural Interface.Micromachines · 2022Article
- Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces.International journal of molecular sciences · 2020Article
- Innervation: the missing link for biofabricated tissues and organs.NPJ Regenerative medicine · 2020Review
- Axonal cytomechanics in neuronal development.Journal of biosciences · 2020Review
- Natural-Based Biomaterials for Peripheral Nerve Injury Repair.Frontiers in bioengineering and biotechnology · 2020Review
- Article
- Coupled circumferential and axial tension driven by actin and myosin influences in vivo axon diameter.Scientific reports · 2017Article
- Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection.Journal of visualized experiments : JoVE · 2017Article
- Myelinating Schwann Cell Polarity and Mechanically-Driven Myelin Sheath Elongation.Frontiers in cellular neuroscience · 2017Review
- Mechanism of Axonal Contractility in Embryonic Drosophila Motor Neurons In Vivo.Biophysical journal · 2016Article
- Rapid Mechanically Controlled Rewiring of Neuronal Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Cyclic mechanical stress modulates neurotrophic and myelinating gene expression of Schwann cells.Cell proliferation · 2015Article
- Tension-driven axon assembly: a possible mechanism.Frontiers in cellular neuroscience · 2015Article
- Stretch induced hyperexcitability of mice callosal pathway.Frontiers in cellular neuroscience · 2015Article
- Mechanical tension modulates local and global vesicle dynamics in neurons.Cellular and molecular bioengineering · 2012Article
- Axon stretch growth: the mechanotransduction of neuronal growth.Journal of visualized experiments : JoVE · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Little is known about extensive nervous system growth after axons reach their targets. Indeed, postnatal animals continue to grow, suggesting that axons are stretched to accommodate the expanding body. We have previously shown that axons can sustain stretch-growth rates reaching 1 cm/day; however, it remained unknown whether the ability to transmit active signals was maintained. Here, stretch-growth did not alter sodium channel activation, inactivation, and recovery or potassium channel activation. In addition, neurons generated normal action potentials that propagated across stretch-grown axons. Surprisingly, Na and K channel density increased due to stretch-growth, which may represent a natural response to preserve the fidelity of neuronal signaling.
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Registered trials
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