ArticleMolecular systems biology2005
Local signaling with molecular diffusion as a decoder of Ca2+ signals in synaptic plasticity.
Article in Molecular systems biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
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- Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice.Frontiers in cellular neuroscience · 2018Article
- Multi-phasic bi-directional chemotactic responses of the growth cone.Scientific reports · 2016Article
- Development of a detailed model of calcium dynamics at the postsynaptic spine of an excitatory synapse.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2016Article
- Control of Ca2+ Influx and Calmodulin Activation by SK-Channels in Dendritic Spines.PLoS computational biology · 2016Article
- Calmodulin transduces Ca2+ oscillations into differential regulation of its target proteins.ACS chemical neuroscience · 2013Article
- Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII.PloS one · 2012Article
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- Calcium messenger heterogeneity: a possible signal for spike timing-dependent plasticity.Frontiers in computational neuroscience · 2011Article
- Postsynaptic signal transduction models for long-term potentiation and depression.Frontiers in computational neuroscience · 2010Article
- Structural plasticity can produce metaplasticity.PloS one · 2009Article
- Hybrid stochastic simulations of intracellular reaction-diffusion systems.Computational biology and chemistry · 2009Article
- Modeling of quantal neurotransmitter release kinetics in the presence of fixed and mobile calcium buffers.Journal of computational neuroscience · 2008Article
- An allosteric model of calmodulin explains differential activation of PP2B and CaMKII.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines.PloS one · 2008Article
- The long journey to a Systems Biology of neuronal function.BMC systems biology · 2007Article
- The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration.BMC neuroscience · 2006Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic plasticity is induced by the influx of calcium ions (Ca2+) through N-methyl-D-aspartate receptors (NMDARs), and the direction and strength of the response depend on the frequency of the synaptic inputs. Recent studies have shown that the direction of synaptic plasticity is also governed by two distinct NMDAR subtypes (NR1/NR2A, NR1/NR2B). How are the different types of regulation (frequency-dependent and receptor-specific) processed simultaneously? To clarify the molecular basis of this dual dependence of synaptic plasticity, we have developed a mathematical model of spatial Ca2+ signaling in a dendritic spine. Our simulations revealed that calmodulin (CaM) activation in the vicinity of NMDARs is strongly affected by the diffusion coefficient of CaM itself, and that this 'local CaM diffusion system' works as a dual decoder of both the frequency of Ca2+ influxes and their postsynaptic current shapes, generated by two NMDAR subtypes, implying that spatial factors may underlie the complicated regulation scheme of synaptic plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.