ArticleMolecular systems biology2005
Gene function prediction from congruent synthetic lethal interactions in yeast.
Article in Molecular systems biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed.
- Role of ZBED3 in PALD1/PIP2- dependent calcium homeostasis during oocyte maturation.Cell & bioscience · 2025Article
- The signalling lipid PI3,5POpen biology · 2023Article
- Yeast Sphingolipid Phospholipase GeneMolecular and cellular biology · 2020Article
- Review
- Why imaging data alone is not enough: AI-based integration of imaging, omics, and clinical data.European journal of nuclear medicine and molecular imaging · 2019Review
- Recent insights into the genotype-phenotype relationship from massively parallel genetic assays.Evolutionary applications · 2019Review
- IdentifyingG3 (Bethesda, Md.) · 2019Article
- High-Throughput Quantitative Genetic Interaction Mapping in the Fission YeastCold Spring Harbor protocols · 2018Article
- Developing a similarity searching module for patient safety event reporting system using semantic similarity measures.BMC medical informatics and decision making · 2017Article
- iSeq: A New Double-Barcode Method for Detecting Dynamic Genetic Interactions in Yeast.G3 (Bethesda, Md.) · 2017Article
- PP2A(Cdc55)'s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function.Scientific reports · 2016Article
- Systematic identification and correction of annotation errors in the genetic interaction map of Saccharomyces cerevisiae.Nucleic acids research · 2016Article
- Yeast as a Heterologous Model System to Uncover Type III Effector Function.PLoS pathogens · 2016Review
- The genetic regulatory network centered on Pto-Wuschela and its targets involved in wood formation revealed by association studies.Scientific reports · 2015Article
- Systematic identification of cell size regulators in budding yeast.Molecular systems biology · 2014Article
- Computational prediction of the human-microbial oral interactome.BMC systems biology · 2014Article
- Comparative study of computational methods for reconstructing genetic networks of cancer-related pathways.Cancer informatics · 2014Review
- Network Assessor: an automated method for quantitative assessment of a network's potential for gene function prediction.Frontiers in genetics · 2014Article
- Genetic interaction networks: better understand to better predict.Frontiers in genetics · 2013Review
- Predicting complex phenotype-genotype interactions to enable yeast engineering: Saccharomyces cerevisiae as a model organism and a cell factory.Biotechnology journal · 2013Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
We predicted gene function using synthetic lethal genetic interactions between null alleles in Saccharomyces cerevisiae. Phenotypic and protein interaction data indicate that synthetic lethal gene pairs function in parallel or compensating pathways. Congruent gene pairs, defined as sharing synthetic lethal partners, are in single pathway branches. We predicted benomyl sensitivity and nuclear migration defects using congruence; these phenotypes were uncorrelated with direct synthetic lethality. We also predicted YLL049W as a new member of the dynein-dynactin pathway and provided new supporting experimental evidence. We performed synthetic lethal screens of the parallel mitotic exit network (MEN) and Cdc14 early anaphase release pathways required for late cell cycle. Synthetic lethal interactions bridged genes in these pathways, and high congruence linked genes within each pathway. Synthetic lethal interactions between MEN and all components of the Sin3/Rpd3 histone deacetylase revealed a novel function for Sin3/Rpd3 in promoting mitotic exit in parallel to MEN. These in silico methods can predict phenotypes and gene functions and are applicable to genomic synthetic lethality screens in yeast and analogous RNA interference screens in metazoans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.