ArticleNucleic acids research1991
Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- Identification of a ModifiedJournal of oncology · 2020Article
- Article
- Conservation of the TGFbeta/Labial homeobox signaling loop in endoderm-derived cells between Drosophila and mammals.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2010Article
- The truncated Hoxa1 protein interacts with Hoxa1 and Pbx1 in stem cells.Journal of cellular biochemistry · 2009Article
- Article
- Expression pattern of HOXB6 homeobox gene in myelomonocytic differentiation and acute myeloid leukemia.Leukemia · 2002Article
- Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome.American journal of human genetics · 2000Article
- Sequence analysis and tissue specific expression of human HOXA7.Molecular biotechnology · 2000Article
- An early phase of embryonic Dlx5 expression defines the rostral boundary of the neural plate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.Nucleic acids research · 1996Article
- Structure and expression of the human trithorax-like gene 1 involved in acute leukemias.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells.Nucleic acids research · 1992Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1991Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The HOX 2.2 homeobox gene is expressed in human hematopoietic cell lines with erythroid features (W.-F. Shen, et al, Proc. Natl. Acad. Sci. 86, 8536-8540, 1989). Both human and murine Hox 2.2 genes contain a single 1 kb intron which interrupts the sequence encoding the proposed homeobox protein. Four human erythroleukemia cell lines express the spliced, homeobox-coding transcript as the major form of message, and variable low amounts of unspliced HOX 2.2 mRNAs. Murine embryonic tissues and adult kidney and uterus contain approximately equal amounts of transcripts containing this intron and mRNAs from which the intron has been excised. The spliced transcript encodes a 224 amino acid homeobox protein, while the unspliced transcript would potentially encode a 140 residue protein containing the same N-terminal sequence but lacking the homeodomain.
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