ArticleEnvironmental health : a global access science source2006
Dioxin-like activities in serum across European and Inuit populations.
Article in Environmental health : a global access science source, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Dioxin-like Activity in Pregnant Women and Indices of Fetal Growth: The ACCEPT Birth Cohort.Toxics · 2022Article
- Time Trend of Persistent Organic Pollutants and Metals in Greenlandic Inuit during 1994-2015.International journal of environmental research and public health · 2021Article
- Detection of aryl hydrocarbon receptor agonists in human samples.Scientific reports · 2018Article
- Dioxin risk assessment: mechanisms of action and possible toxicity in human health.Environmental science and pollution research international · 2015Review
- Integrated ecological risk assessment of dioxin compounds.Environmental science and pollution research international · 2015Review
- Biomonitoring and hormone-disrupting effect biomarkers of persistent organic pollutants in vitro and ex vivo.Basic & clinical pharmacology & toxicology · 2014Review
- Association between environmental contaminants and health outcomes in indigenous populations of the Circumpolar North.International journal of circumpolar health · 2014Review
- Effects of perfluoroalkyl acids on the function of the thyroid hormone and the aryl hydrocarbon receptor.Environmental science and pollution research international · 2013Article
- Article
- Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: a case control study.Environmental health : a global access science source · 2011Article
- A cross-sectional study of the association between persistent organic pollutants and glucose intolerance among Greenland Inuit.Diabetologia · 2008Article
- Xenohormone transactivities are inversely associated to serum POPs in Inuit.Environmental health : a global access science source · 2008Article
- Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines.Environmental health perspectives · 2008Review
- Endocrine-disrupting potential of bisphenol A, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: new data and a brief review.Environmental health perspectives · 2007Article
- Xenoandrogenic activity in serum differs across European and Inuit populations.Environmental health perspectives · 2007Article
- Semen quality in relation to xenohormone and dioxin-like serum activity among Inuits and three European populations.Environmental health perspectives · 2007Article
- AhR transcriptional activity in serum of Inuits across Greenlandic districts.Environmental health : a global access science source · 2007Article
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Authors and funding
13 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersistent organic pollutants (POPs) such as polychlorinated dibenzo-p-dioxins/furans, polychlorinated biphenyls (PCBs) and organochlorine pesticides can cause a series of adverse effects on e.g. reproduction in animals and humans, many of which involve the aryl hydrocarbon receptor (AhR). The aim of the present study was to compare the integrated serum level of AhR mediated activity among European and Inuit populations, and evaluate whether the activity was associated to the selected POP markers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE).
methodsThe study included 338 males from Greenland (Inuit's), Sweden, Warsaw (Poland) and Kharkiv (Ukraine). The AhR transactivity of serum extracts alone (AhRag) and competitive AhR activity (AhRcomp) upon co-exposure with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were determined in the lipophilic serum fraction containing the POPs using the AhR mediated luciferase reporter Hepa1.12cR cell assay.
resultsThe European groups showed higher median level of AhR-TEQ (TCDD toxic equivalents) compared to the Inuit's, whereas higher incidence of Inuits sample further induced AhRcomp activity. Neither AhRag nor AhR-TEQ were correlated to CB-153 or p,p'-DDE for any of the study groups. Multiple regressions showed a significant heterogeneity of association between the CB-153 and the AhRcomp across the study groups, and accordingly a negative association between AhRcomp and CB-153 was found for the Kharkiv group.
conclusionNo consistent correlation between AhR activities and two POP markers was found. Although the difference of AhRag between European and Inuit men could not be explained by CB-153 or p,p'-DDE levels alone, we believe that the variation of AhR serum activity reflects different pattern of POP exposure, genetics and/or life style factors.
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