ReviewCellular and molecular neurobiology
Protease pathways in peptide neurotransmission and neurodegenerative diseases.
Review in Cellular and molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Proteases: Role in Various Human Diseases.Current pharmaceutical biotechnology · 2025Review
- Deciphering the Role of EGL-3 for Neuropeptides Processing in Caenorhabditis elegans Using High-Resolution Quadrupole-Orbitrap Mass Spectrometry.Neurochemical research · 2018Article
- Article
- Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.Current Alzheimer research · 2015Article
- Opioid system and Alzheimer's disease.Neuromolecular medicine · 2012Review
- What can we learn from study of Alzheimer's disease in patients with Down syndrome for early-onset Alzheimer's disease in the general population?Alzheimer's research & therapy · 2011Article
- Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics.Journal of neurochemistry · 2010Article
- Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis.Journal of neurochemistry · 2010Article
- Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome.Molecular & cellular proteomics : MCP · 2009Article
- Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment.The Journal of biological chemistry · 2008Article
- Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes.Biochimica et biophysica acta · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Recent research demonstrates the critical importance of neuroproteases for the production of peptide neurotransmitters, and for the production of toxic peptides in major neurodegenerative diseases that include Alzheimer's (AD) and Huntington's diseases. This review describes the strategies utilized to identify the appropriate proteases responsible for producing active peptides for neurotransmission, with application of such approaches for defining protease mechanisms in neurodegenerative diseases. 2. Integration of multidisciplinary approaches in neurobiology, biochemistry, chemistry, proteomics, molecular biology, and genetics has been utilized for neuroprotease studies. These investigations have identified secretory vesicle cathepsin L for the production of the enkephalin opioid peptide neurotransmitter and other neuropeptides. Furthermore, new results using these strategies have identified secretory vesicle cathepsin B for the production of beta-amyloid (Abeta) in the major regulated secretory pathway that provides activity-dependent secretion of Abeta peptides, which accumulate in AD. 3. CNS neuroproteases that participate in peptide neurotransmission and in neurodegenerative diseases represent new candidate drug targets that may be explored in future research for the development of novel therapeutic agents for neurological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.