Trial reportJournal of perinatology : official journal of the California Perinatal Association2006
Comparing two methods of delivering high-flow gas therapy by nasal cannula following endotracheal extubation: a prospective, randomized, masked, crossover trial.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Humidified High Flow Nasal Cannula to Nasal Continuous Positive Airway Pressure for Non-Invasive Respiratory Support in Neonates
Humidified High Flow Nasal Cannula Versus Nasal Intermittent Positive Ventilation in Neonates as Primary Respiratory Support:a Randomized Controlled Trial
Adaptive Dynamic Inspiratory Nasal Apparatus (ADINA): Comparison to High Flow Nasal Cannula (HFNC)
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- High flow nasal cannula for respiratory support in term infants.The Cochrane database of systematic reviews · 2023Pooled it
- High flow nasal cannula for respiratory support in preterm infants.The Cochrane database of systematic reviews · 2016Pooled it
- The effects of a 2-h trial of high-flow oxygen by nasal cannula versus Venturi mask in immunocompromised patients with hypoxemic acute respiratory failure: a multicenter randomized trial.Critical care (London, England) · 2015Trial
- Direct extubation onto high-flow nasal cannulae post-cardiac surgery versus standard treatment in patients with a BMI ≥30: a randomised controlled trial.Intensive care medicine · 2015Trial
- Mechanisms of nasal high flow on ventilation during wakefulness and sleep.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- High-flow nasal cannula and extubation success in the premature infant: a comparison of two modalities.Journal of perinatology : official journal of the California Perinatal Association · 2010Trial
- Hemodynamic changes in preterm neonates with respiratory distress syndrome: high-flow nasal cannula versus nasal continuous positive airway pressure-a randomized controlled trial.Pediatric research · 2026Article
- Nasal Injuries Related to Respiratory Support Interfaces in Preterm Infants: Neonatal Course and 12-Month Outcome.Children (Basel, Switzerland) · 2025Article
- Reporting nasal pressure injuries in neonates receiving non-invasive ventilation: a scoping review.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Nasal high flow therapy for primary respiratory support in preterm infants.The Cochrane database of systematic reviews · 2023Review
- Review
- Non-invasive ventilation in neonates: a review of current literature.Frontiers in pediatrics · 2023Review
- Comparative evaluation of high-flow nasal cannula oxygenation vs nasal intermittent ventilation in postoperative paediatric patients operated for acyanotic congenital cardiac defects.Medical journal, Armed Forces India · 2022Article
- Helmet Ventilation for Pediatric Patients During the COVID-19 Pandemic: A Narrative Review.Frontiers in pediatrics · 2022Review
- The Comparison of HHHFNC and NCPAP in Extremely Low-Birth-Weight Preterm Infants After Extubation: A Single-Center Randomized Controlled Trial.Frontiers in pediatrics · 2020Article
- Differential impact of flow and mouth leak on oropharyngeal humidification during high-flow nasal cannula: a neonatal bench study.World journal of pediatrics : WJP · 2018Article
- Consensus approach to nasal high-flow therapy in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- [Application of humidified high-flow nasal cannula in neonates with meconium aspiration syndrome and pulmonary hypertension after extubation].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Nasal high flow treatment in preterm infants.Maternal health, neonatology and perinatology · 2017Review
- High-flow nasal cannula therapy for adult patients.The Journal of international medical research · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe compared two methods of delivering high-flow gas therapy by nasal cannula, applied immediately after planned endotracheal extubations of NICU patients. STUDY DESIGN AND
methodsThirty NICU patients who were about to be extubated from mechanical ventilation were randomized into two groups; Group 1 received Vapotherm for the first 24 h after extubation, then standard high-flow nasal cannula for the next 24 h, and Group 2 received standard high-flow therapy for the first 24 h, then Vapotherm for the next 24 h. At 24 h after extubation and again 48 h after extubation, a neonatologist who was not aware which modality the patient had been receiving examined the nasal mucosa and applied a scoring system. A research nurse who was unaware of the modality abstracted respiratory rates and respiratory effort scores from a specific study-bedside record. The experimental design was such that a patient could 'fail' extubation either by reintubation for mechanical ventilation, or by rescue to the opposite modality before completing the 24-h test period.
resultsFifteen patients were randomized to Group 1 and 15 to Group 2. No differences were apparent between the groups in birth weight, gestational age, age at study entry, gender or underlying pulmonary disorder. Respiratory rates were similar while on Vapotherm (52+/-13 breaths/min, mean+/-s.d.) and high-flow (54+/-14/min). At 24 h after starting the modality, those on Vapotherm had more normal examinations of the nasal mucosa (2.7+/-1.2 vs 7.8+/-1.7, P < 0.0005) and lower respiratory effort scores (1.2+/-0.6 vs 2.0+/-0.9, P < 0.05) than did those on high-flow. No patients failed while on Vapotherm, but seven failed while on high-flow (two reintubations and five rescue switches to Vapotherm, P < 0.005).
conclusionsAmong NICU patients immediately following extubation, Vapotherm performed better than a standard high-flow nasal cannula in maintaining a normal appearing nasal mucosa, a lower respiratory effort score, and averting reintubation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.