ArticleThe American journal of pathology2006
Adeno-associated virus-2 (AAV-2) causes trophoblast dysfunction, and placental AAV-2 infection is associated with preeclampsia.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2022Pooled it
- Association between maternal infections and preeclampsia: a systematic review of epidemiologic studies.Maternal and child health journal · 2008Pooled it
- The Immunopathology of Preeclampsia.Biomedicines · 2026Review
- COVID-19 vaccination status during pregnancy and preeclampsia risk: the pandemic-era cohort of the INTERCOVID consortium.EClinicalMedicine · 2026Article
- Deep metagenomic characterization of the gut virome in pregnant women with preeclampsia.mSphere · 2024Article
- Gestational Viral Infections: Role of Host Immune System.Microorganisms · 2023Review
- Activation of the Interferon Pathway in Trophoblast Cells Productively Infected with SARS-CoV-2.Stem cells and development · 2023Article
- Adeno-associated virus infection and its impact in human health: an overview.Virology journal · 2022Review
- Metagenomic profiling of placental tissue suggests DNA virus infection of the placenta is rare.The Journal of general virology · 2021Article
- Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis.Frontiers in cell and developmental biology · 2021Article
- Human infectious diseases and risk of preeclampsia: an updated review of the literature.Infection · 2017Review
- Cellular and molecular mechanisms of viral infection in the human placenta.Pathogens and disease · 2017Review
- Risks associated with viral infections during pregnancy.The Journal of clinical investigation · 2017Review
- A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning.Journal of visualized experiments : JoVE · 2015Article
- Large scale aggregate microarray analysis reveals three distinct molecular subclasses of human preeclampsia.PloS one · 2015Article
- New insights into the relationship between viral infection and pregnancy complications.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Article
- Article
- Placental Toll-like receptor 3 and Toll-like receptor 7/8 activation contributes to preeclampsia in humans and mice.PloS one · 2012Article
- Parvovirus infection-induced cell death and cell cycle arrest.Future virology · 2010Article
- Porphyromonas gingivalis invades human trophoblasts and inhibits proliferation by inducing G1 arrest and apoptosis.Cellular microbiology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Shallow invasion by extravillous trophoblast cells into the uterine wall reduces placental perfusion and causes placental dysfunction, but the one or more causes of shallow placental invasion are unknown. We hypothesized that infection with adeno-associated virus-2 (AAV-2) inhibits trophoblast invasion and is associated with preeclampsia, which is a common obstetric complication resulting from placental dysfunction. We determined that transformed extravillous trophoblast (HTR-8/SVneo) cells were susceptible to AAV-2 infection in the presence or absence of adenovirus, which provides helper function for AAV-2 replication, and that AAV-2 infection reduced invasion of HTR-8/SVneo cells through an extracellular matrix before cytopathic effects were detected. In a case-control study, AAV-2 DNA was found more frequently in trophoblast cells from cases of severe preeclampsia (22/40) than from normal term deliveries (5/27, P = 0.002). These results indicate that AAV-2 infection is a previously unidentified cause of placental dysfunction. Additional studies to determine the susceptibility of extravillous trophoblast to other viruses, and the mechanisms by which viral infection impairs placental function, are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.