ArticleAntimicrobial agents and chemotherapy2006
Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
39 citing papers in PubMed, 89 citations in OpenAlex.
- Molecular analysis of squalene epoxidase gene mutations in Trichophyton rubrum from clinical onychomycosis samples in South Korea.Scientific reports · 2026Article
- Rising antifungal resistance inFrontiers in microbiology · 2026Review
- [Development of resistance in skin fungi : Molecular mechanisms, antifungal resistance assays, risk factors, and diagnostic regime-challenges for medical treatment].Dermatologie (Heidelberg, Germany) · 2025Review
- Prevalence ofPathogens (Basel, Switzerland) · 2025Article
- Dermatophytes: Update on Clinical Epidemiology and Treatment.Mycopathologia · 2024Review
- Innovations in Antifungal Drug Discovery among Cell Envelope Synthesis Enzymes through Structural Insights.Journal of fungi (Basel, Switzerland) · 2024Review
- [Recurrent tinea corporis generalisata due to Terbinafine-resistant Trichophyton rubrum strain : Long-term treatment with super bioavailability itraconazole].Dermatologie (Heidelberg, Germany) · 2023Review
- Time to Think Antifungal Resistance Increased Antifungal Resistance Exacerbates the Burden of Fungal Infections Including Resistant Dermatomycoses.Pathogens & immunity · 2023Article
- European Hedgehogs (Erinaceus europaeus L.) as a Reservoir of Dermatophytes in Poland.Microbial ecology · 2022Article
- Terbinafine Resistance in Dermatophytes: A French Multicenter Prospective Study.Journal of fungi (Basel, Switzerland) · 2022Article
- Phylogeny, Antifungal Susceptibility, and Point Mutations ofFrontiers in cellular and infection microbiology · 2022Article
- Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies.Journal of fungi (Basel, Switzerland) · 2021Review
- Molecular Epidemiology and Antifungal Susceptibility ofJournal of fungi (Basel, Switzerland) · 2021Article
- The Growing Problem of Antifungal Resistance in Onychomycosis and Other Superficial Mycoses.American journal of clinical dermatology · 2021Article
- Strategies to Better Target Fungal Squalene Monooxygenase.Journal of fungi (Basel, Switzerland) · 2021Review
- Article
- Rapid detection of terbinafine resistance in Trichophyton species by Amplified refractory mutation system-polymerase chain reaction.Scientific reports · 2020Article
- Emergence of Terbinafine ResistantInfection and drug resistance · 2020Article
- Emerging Terbinafine Resistance inAntimicrobial agents and chemotherapy · 2019Article
- Recent Findings in Onychomycosis and Their Application for Appropriate Treatment.Journal of fungi (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.