ArticleNucleic acids research2006
Human Rad51 protein displays enhanced homologous pairing of DNA sequences resembling those at genetically unstable loci.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Association of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity.PloS one · 2016Article
- Ride the wavelet: A multiscale analysis of genomic contexts flanking small insertions and deletions.Genome research · 2009Article
- Rad52 promotes second-end DNA capture in double-stranded break repair to form complement-stabilized joint molecules.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
DNA strand exchange, the central step of homologous recombination, is considered to occur approximately independently of DNA sequence content. However, certain prokaryotic and eukaryotic genomic loci display either an enhanced or reduced frequency of genetic exchange. Here we show that the Homo sapiens DNA strand exchange protein, HsRad51, shows a preference for binding to single-stranded DNA sequences primarily rich in G-residues and poor in A- and C-residues, and that these DNA sequences manifest enhanced HsRad51 protein-dependent homologous pairing. Both of these properties are common to all DNA strand exchange proteins examined thus far. These preferred DNA pairing sequences resemble those found at genetic loci in human cells that cause genomic instability and lead to genetic diseases.
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