Trial reportBritish journal of clinical pharmacology2006
Does gender, food or grapefruit juice alter the pharmacokinetics of primaquine in healthy subjects?
Trial report in British journal of clinical pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Bioequivalence of a new coated 15 mg primaquine formulation for malaria elimination.Malaria journal · 2024Trial
- Pharmacokinetic interactions between primaquine and pyronaridine-artesunate in healthy adult Thai subjects.Antimicrobial agents and chemotherapy · 2015Trial
- Pharmacokinetic interactions between primaquine and chloroquine.Antimicrobial agents and chemotherapy · 2014Trial
- Simultaneous and enantiospecific quantification of primaquine and carboxyprimaquine in human plasma using liquid chromatography-tandem mass spectrometry.Malaria journal · 2022Article
- Measurements of 5,6-Orthoquinone, a Surrogate for the Presumed Active Primaquine Metabolite 5-Hydroxyprimaquine, in the Urine of Cambodian Adults.Antimicrobial agents and chemotherapy · 2022Article
- Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria.Malaria journal · 2021Article
- Enhancing the antimalarial activity of artesunate.Parasitology research · 2020Review
- Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population.The Journal of infectious diseases · 2019Article
- Primaquine Pharmacokinetics in Lactating Women and Breastfed Infant Exposures.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Article
- Review
- Primaquine in Plasma and Methemoglobinemia in Patients with Malaria Due toThe American journal of tropical medicine and hygiene · 2017Article
- An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia.BMC medicine · 2016Article
- Management of relapsing Plasmodium vivax malaria.Expert review of anti-infective therapy · 2016Review
- Review: Malaria chemoprophylaxis for travelers to Latin America.The American journal of tropical medicine and hygiene · 2011Review
- Review: Improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations.The American journal of tropical medicine and hygiene · 2011Review
- Increased bioavailability of primaquine using poly(ethylene oxide) matrix extended-release tablets administered to beagle dogs.Annals of tropical medicine and parasitology · 2011Article
- The effect of grapefruit juice on drug disposition.Expert opinion on drug metabolism & toxicology · 2011Review
- Grapefruit-drug interactions.Drugs · 2010Review
- Pharmacokinetics of single-dose primaquine in patients with chronic kidney dysfunction.Indian journal of pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate the effects of gender, food and grapefruit juice on the pharmacokinetics of primaquine in healthy subjects.
methodsIn a randomized, two-phase cross-over study, 10 male and 10 female healthy Vietnamese subjects were administered 30 mg primaquine in the fasting state or with food, followed by administration of primaquine with grapefruit juice.
resultsThe pharmacokinetics of primaquine were comparable between male and female subjects, with geometric mean ratios of Cmax = 0.89 [95% confidence interval (CI) 0.65, 1.22] and AUC = 0.80 (95% CI 0.56, 1.15). The mean CL/F of primaquine was slightly higher in males than in females [0.52 l h(-1) kg(-1)vs. 0.43 l h(-1) kg(-1), mean difference of 0.09 (95% CI -0.10, 0.28), P = 0.32]. When compared with fasting state values, food increased the geometric mean Cmax of primaquine by 26% (95% CI 12, 40) and the AUC by 14% (95% CI 3, 27). Similarly, grapefruit juice increased the geometric mean Cmax by 23% (95% CI 4, 45) and the AUC by 19% (95% CI 4, 37).
conclusionsThe disposition of primaquine was comparable between genders, suggesting no need to modify the dose of primaquine for malaria treatment or prophylaxis. Food increased the oral bioavailability of primaquine, which may lead to higher antimalarial efficacy. Grapefruit juice increased the bioavailability of primaquine, with marked interindividual differences suggesting that people should not take primaquine with grapefruit juice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.