ArticleHuman genetics2006
ITGB3 shows genetic and expression interaction with SLC6A4.
Article in Human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder.Experimental brain research · 2022Review
- p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging.Molecular autism · 2018Article
- The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders.PLoS genetics · 2017Article
- Integrins in synapse regulation.Nature reviews. Neuroscience · 2016Review
- The serotonin system in autism spectrum disorder: From biomarker to animal models.Neuroscience · 2016Review
- Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Neuroimaging endophenotypes in animal models of autism spectrum disorders: lost or found in translation?Psychopharmacology · 2014Review
- Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas.Autism research : official journal of the International Society for Autism Research · 2014Article
- Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome.Molecular autism · 2013Article
- Neuroanatomical Assessment of the Integrin β3 Mouse Model Related to Autism and the Serotonin System Using High Resolution MRI.Frontiers in psychiatry · 2012Article
- Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes.European journal of human genetics : EJHG · 2011Article
- Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: initial studies and future directions.Autism research : official journal of the International Society for Autism Research · 2011Article
- Article
- Association and gene-gene interaction of SLC6A4 and ITGB3 in autism.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- The serotonergic system: its role in pathogenesis and early developmental treatment of autism.Current neuropharmacology · 2009Article
- Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse.Journal of neurodevelopmental disorders · 2009Article
- Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: efficient identification of known microduplications and identification of a novel microduplication in ASMT.BMC medical genomics · 2008Article
- Multifactor dimensionality reduction-phenomics: a novel method to capture genetic heterogeneity with use of phenotypic variables.American journal of human genetics · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Autism affects more males than females and is associated with disturbances of the serotonin system. The integrin beta3 (ITGB3) and serotonin transporter (SLC6A4) genes were both recently identified as male quantitative trait loci (QTLs) for serotonin levels and alleles of each have been associated with autism. Here, we use publicly available genomic resources to determine whether regulation of expression level could be the mechanism behind association between serotonin level and noncoding variation in ITGB3. We also examine whether ITGB3 might interact with SLC6A4 to contribute to autism susceptibility. Using murine and human expression data, we observe that ITGB3 and SLC6A4 expression levels are correlated (0.38<r<0.78). Moreover, genetic variation in ITGB3 is associated with expression of both ITGB3 (P=0.012) and SLC6A4 (P=0.008) in unrelated CEPH individuals. We also show preliminary evidence that genotypes at the ITGB3 and SLC6A4 loci may interact to affect autism susceptibility (P=0.033).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.