ArticleJournal of human genetics2006
A common functional exon polymorphism in the microsomal triglyceride transfer protein gene is associated with type 2 diabetes, impaired glucose metabolism and insulin levels.
Article in Journal of human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Association between Genotype and the Glycemic Response to an Oral Glucose Tolerance Test: A Systematic Review.Nutrients · 2023Pooled it
- Signatures of Convergent Evolution and Natural Selection at the Alcohol Dehydrogenase Gene Region are Correlated with Agriculture in Ethnically Diverse Africans.Molecular biology and evolution · 2022Article
- Differences in the genetic backgrounds of patients with alcoholic liver disease and non-alcoholic fatty liver disease.JGH open : an open access journal of gastroenterology and hepatology · 2019Article
- Identification of deleterious rare variants in MTTP, PNPLA3, and TM6SF2 in Japanese males and association studies with NAFLD.Lipids in health and disease · 2017Article
- Association of L-FABP T94A and MTP I128T polymorphisms with hyperlipidemia in Chinese subjects.Lipids · 2015Article
- Non-alcoholic fatty liver disease and diabetes: from physiopathological interplay to diagnosis and treatment.World journal of gastroenterology · 2014Review
- Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight.Genes & nutrition · 2014Article
- Microsomal triglyceride transfer protein -164 T > C gene polymorphism and risk of cardiovascular disease: results from the EPIC-Potsdam case-cohort study.BMC medical genetics · 2013Article
- Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Article
- Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans.Diabetes · 2008Article
- Postprandial triglyceride response in men: role of overweight, abdominal fat and nutrition.Obesity facts · 2008Article
- Dietary fat, genes and insulin sensitivity.Journal of molecular medicine (Berlin, Germany) · 2007Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apolipoprotein B-containing lipoproteins. Emerging evidence has indicated that the functional MTP exon polymorphism I128T is associated with dyslipidemia and other traits of the insulin-resistance syndrome, and the T128 variant seems to confer a reduced stability of MTP, resulting in reduced binding of LDL particles. The aim of the study was to elucidate the association of this MTP polymorphism with parameters of postprandial metabolism. A total of 716 male subjects from a postprandially characterized cohort (MICK) and a nested case-control study (EPIC) of 190 incident type 2 diabetes cases and 380 sex- or age-matched controls were genotyped for the I128T exon polymorphism. In comparison to homozygote subjects of the wild allele, carriers of the less common allele of the MTP T128 genotype showed significantly lower postprandial insulin levels (P=0.017), lower diastolic blood pressure (P=0.049) and had a lower prevalence of impaired glucose metabolism and diabetes type 2 (P=0.03) in the MICK. Consistent with this, we found a lower incidence of type 2 diabetes in male subjects of the nested case-control study in the T128 genotype (P=0.007). These results suggest that the rare allele of the MTP I128T polymorphism may be protective against impaired glucose tolerance, type 2 diabetes and other parameters of the metabolic syndrome.
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