ArticleNature methods2006
Interrogation of genomes by molecular copy-number counting (MCC).
Article in Nature methods, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
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- Current status of comprehensive chromosome screening for elective single-embryo transfer.Obstetrics and gynecology international · 2014Review
- IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer.International journal of experimental pathology · 2013Article
- Current analysis platforms and methods for detecting copy number variation.Physiological genomics · 2013Review
- Article
- Limiting dilution bisulfite (pyro)sequencing reveals parent-specific methylation patterns in single early mouse embryos and bovine oocytes.Epigenetics · 2011Article
- Single-molecule analysis of genome rearrangements in cancer.Nucleic acids research · 2011Article
- Genomic evidence of pre-invasive clonal expansion, dispersal and progression in bronchial dysplasia.The Journal of pathology · 2011Article
- Using next-generation sequencing for high resolution multiplex analysis of copy number variation from nanogram quantities of DNA from formalin-fixed paraffin-embedded specimens.Nucleic acids research · 2010Article
- Distinct genomic alterations in prostate cancers in Chinese and Western populations suggest alternative pathways of prostate carcinogenesis.Cancer research · 2010Article
- Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer.American journal of respiratory and critical care medicine · 2010Article
- Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21.Haematologica · 2009Article
- Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Disruption of ETV6 in intron 2 results in upregulatory and insertional events in childhood acute lymphoblastic leukaemia.Leukemia · 2008Article
- An efficient method for multi-locus molecular haplotyping.Nucleic acids research · 2007Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
Human cancers and some congenital traits are characterized by cytogenetic aberrations including translocations, amplifications, duplications or deletions that can involve gain or loss of genetic material. We have developed a simple method to precisely delineate such regions with known or cryptic genomic alterations. Molecular copy-number counting (MCC) uses PCR to interrogate miniscule amounts of genomic DNA and allows progressive delineation of DNA content to within a few hundred base pairs of a genomic alteration. As an example, we have located the junctions of a recurrent nonreciprocal translocation between chromosomes 3 and 5 in human renal cell carcinoma, facilitating cloning of the breakpoint without recourse to genomic libraries. The analysis also revealed additional cryptic chromosomal changes close to the translocation junction. MCC is a fast and flexible method for characterizing a wide range of chromosomal aberrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.