ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2006
Host Lewis phenotype-dependent Helicobacter pylori Lewis antigen expression in rhesus monkeys.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Probing the expression and adhesion of glycans involved in Helicobacter pylori infection.Scientific reports · 2024Article
- Animal Models andJournal of clinical medicine · 2022Review
- The Biosynthesis of Lipooligosaccharide frommBio · 2018Article
- Genotypic and phenotypic variation of Lewis antigen expression in geographically diverse Helicobacter pylori isolates.Helicobacter · 2011Article
- Clinical relevance and diversity of two homologous genes encoding glycosyltransferases in Helicobacter pylori.Journal of clinical microbiology · 2010Article
- Surreptitious manipulation of the human host by Helicobacter pylori.Gut microbes · 2010Article
- Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Leb-transgenic mice.The Journal of experimental medicine · 2009Article
- Helicobacter pylori lipopolysaccharide modification, Lewis antigen expression, and gastric colonization are cholesterol-dependent.BMC microbiology · 2009Article
- Article
- Lipopolysaccharide diversity evolving in Helicobacter pylori communities through genetic modifications in fucosyltransferases.PloS one · 2008Article
- Article
- Parental family structure, Helicobacter pylori, and gastric adenocarcinoma.PLoS medicine · 2007Review
- Early-life family structure and microbially induced cancer risk.PLoS medicine · 2007Article
- Phase variation in Helicobacter pylori lipopolysaccharide due to changes in the lengths of poly(C) tracts in alpha3-fucosyltransferase genes.Infection and immunity · 1999Article
- Role of futC slipped strand mispairing in Helicobacter pylori Lewisy phase variation.Microbes and infectionArticle
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Authors and funding
6 authors.
Funding
Abstract
Both human and H. pylori populations are polymorphic for the expression of Lewis antigens. Using an experimental H. pylori challenge of rhesus monkeys of differing Lewis phenotypes, we aimed to determine whether H. pylori populations adapt their Lewis phenotypes to those of their hosts. After inoculation of four monkeys with a mixture of seven strains identified by RAPD-polymerase chain reaction, H. pylori Lewis expression was followed in 86 isolates obtained over 40 wk. Host Lewis(a/b) secretion status was characterized by immunological assays. Fingerprints of the predominating strain (J166) were identical in all four animals after 40 wk, but its Lewis phenotype had substantial variability in individual hosts. At 40 wk, J166 populations from two Lewis(a-b+) animals predominantly expressed Lewis(y). In contrast, J166 populations had switched to a Lewis(x) dominant phenotype in the two Lewis(a+b-) animals; a frame shift in futC, regulating conversion of Lewis(x) to Lewis(y), accounted for the phenotypic switch. The results indicate that individual cells in H. pylori populations can change Lewis phenotypes during long-term colonization of natural hosts to resemble those of their hosts, providing evidence for host selection for bacterial phenotypes.
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