ArticleJournal of cell science2006
Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells.
Article in Journal of cell science, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
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- RpS13 controls the homeostasis of germline stem cell niche through Rho1-mediated signals in the Drosophila testis.Cell proliferation · 2020Article
- Heterophilic cell-cell adhesion of atypical cadherins Fat and Dachsous regulate epithelial cell size dynamics duringMolecular biology of the cell · 2020Article
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- Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet.Genetics · 2016Article
- Loss of Drosophila pseudouridine synthase triggers apoptosis-induced proliferation and promotes cell-nonautonomous EMT.Cell death & disease · 2015Article
- Soma influences GSC progeny differentiation via the cell adhesion-mediated steroid-let-7-Wingless signaling cascade that regulates chromatin dynamics.Biology open · 2015Article
- E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion.Molecular biology of the cell · 2014Article
- Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling.Progress in molecular biology and translational science · 2013Review
- Wnt signaling: the β-cat(enin)'s meow.Genes & development · 2012Article
- Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II.Developmental biology · 2010Article
- Wnt signalling and the control of cellular metabolism.The Biochemical journal · 2010Review
- Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity.Cold Spring Harbor perspectives in biology · 2009Review
- Dual role of wingless signaling in stem-like hematopoietic precursor maintenance in Drosophila.Developmental cell · 2009Article
- Article
- Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development.Developmental biology · 2007Article
- Wnt, Hedgehog and junctional Armadillo/beta-catenin establish planar polarity in the Drosophila embryo.PloS one · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Armadillo, the Drosophila homolog of beta-catenin, plays a crucial role in both the Wingless signal transduction pathway and cadherin-mediated cell-cell adhesion, raising the possibility that Wg signaling affects cell adhesion. Here, we use a tissue culture system that allows conditional activation of the Wingless signaling pathway and modulation of E-cadherin expression levels. We show that activation of the Wingless signaling pathway leads to the accumulation of hypophosphorylated Armadillo in the cytoplasm and in cellular processes, and to a concomitant reduction of membrane-associated Armadillo. Activation of the Wingless pathway causes a loss of E-cadherin from the cell surface, reduced cell adhesion and increased spreading of the cells on the substratum. After the initial loss of E-cadherin from the cell surface, E-cadherin gene expression is increased by Wingless. We suggest that Wingless signaling causes changes in Armadillo levels and subcellular localization that result in a transient reduction of cadherin-mediated cell adhesion, thus facilitating cell shape changes, division and movement of cells in epithelial tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.