ReviewCritical care (London, England)2006
Clinical review: thyroid hormone replacement in children after cardiac surgery--is it worth a try?
Review in Critical care (London, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Trial
- Effect of perioperative use of oral triidothyronine for infants undergoing complex congenital cardiac surgeries under cardiopulmonary bypass: A double-blinded randomised controlled study.Annals of cardiac anaesthesiaTrial
- Cardiac Endocrine Function and Hormonal Interplay in Pediatrics: From Development to Clinical Implications.Biomedicines · 2025Review
- Changes of serum TSH, FT3, and FT4 levels in infants received surgical correction of congenital heart disease under cardiopulmonary bypass.BMC cardiovascular disorders · 2023Article
- Thyroid Hormones and Health-Related Quality of Life in Normal Pressure Hydrocephalus Patients before and after the Ventriculoperitoneal Shunt Surgery: A Longitudinal Study.Journal of clinical medicine · 2022Article
- Transcutaneous Absorption of Iodine in Pediatric Cardiac Surgery Following the Topical Use of Povidone Iodine.ARYA atherosclerosis · 2022Article
- Patterns and Determinants of Change in Cortisol Levels and Thyroid Function as a Function of Cardiac Risk in Children Undergoing Cardiac Surgery.International journal of pediatrics · 2022Article
- Transient Secondary Hypothyroidism and Thyroid Hormone Replacement Therapy in Pediatric Postoperative Cardiopulmonary Bypass.Current cardiology reviews · 2018Article
- Thyroid hormones and cardiovascular disease.Nature reviews. Cardiology · 2017Review
- Thyroid Hormone in the Pediatric Intensive Care Unit.Journal of pediatric intensive care · 2016Review
- Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions.Endocrine reviews · 2014Review
- Low triiodothyronine predicts mortality in critically ill patients.Indian journal of endocrinology and metabolism · 2013Article
- Serum thyroid hormone profile in critically Ill children.Indian journal of pediatrics · 2009Article
- Nonthyroidal illness syndrome in children.Endocrine · 2009Review
- The dilemma of the nonthyroidal illness syndrome.Acta bio-medica : Atenei Parmensis · 2008Article
- Thyroid function status and its impact on clinical outcome in patients admitted to critical care.Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac surgery using cardiopulmonary bypass produces a generalized systemic inflammatory response, resulting in increased postoperative morbidity and mortality. Under these circumstances, a typical pattern of thyroid abnormalities is seen in the absence of primary disease, defined as sick euthyroid syndrome (SES). The presence of postoperative SES mainly in small children and neonates exposed to long bypass times and the pharmacological profile of thyroid hormones and their effects on the cardiovascular physiology make supplementation therapy an attractive treatment option to improve postoperative morbidity and mortality. Many studies have been performed with conflicting results. In this article, we review the important literature on the development of SES in paediatric postoperative cardiac patients, analyse the existing information on thyroid hormone replacement therapy in this patient group and try to summarize the findings for a recommendation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.