ArticleArthritis research & therapy2006
Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff.
Article in Arthritis research & therapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- The subacromial bursa in rotator cuff injury: from pathological contributor to regenerative resource?Frontiers in bioengineering and biotechnology · 2026Review
- Removal or retention: evolving views on possible roles of the subacromial bursa in rotator cuff disease.EFORT open reviews · 2025Review
- Review
- Histological and molecular features of the subacromial bursa of rotator cuff tears compared to non-tendon defects: a pilot study.BMC musculoskeletal disorders · 2021Article
- Decreased Colony-Forming Ability of Subacromial Bursa-Derived Cells During Revision Arthroscopic Rotator Cuff Repair.Arthroscopy, sports medicine, and rehabilitation · 2021Article
- Higher BMP Expression in Tendon Stem/Progenitor Cells Contributes to the Increased Heterotopic Ossification in Achilles Tendon With Aging.Frontiers in cell and developmental biology · 2020Article
- Characterization of bursa subacromialis-derived mesenchymal stem cells.Stem cell research & therapy · 2015Article
- Ossifying tendinitis of the rotator cuff after arthroscopic excision of calcium deposits: report of two cases and literature review.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2015Review
- Gremlin-2 is a BMP antagonist that is regulated by the circadian clock.Scientific reports · 2014Article
- Higher BMP/Smad sensitivity of tendon-derived stem cells (TDSCs) isolated from the collagenase-induced tendon injury model: possible mechanism for their altered fate in vitro.BMC musculoskeletal disorders · 2013Article
- Altered fate of tendon-derived stem cells isolated from a failed tendon-healing animal model of tendinopathy.Stem cells and development · 2013Article
- Heterotopic mineralization (ossification or calcification) in tendinopathy or following surgical tendon trauma.International journal of experimental pathology · 2012Review
- A systematic review of the histological and molecular changes in rotator cuff disease.Bone & joint research · 2012Article
- Expression of chondro-osteogenic BMPs in clinical samples of patellar tendinopathy.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Article
- Higher BMP receptor expression and BMP-2-induced osteogenic differentiation in tendon-derived stem cells compared with bone-marrow-derived mesenchymal stem cells.International orthopaedics · 2012Article
- Tendon-derived stem cells (TDSCs): from basic science to potential roles in tendon pathology and tissue engineering applications.Stem cell reviews and reports · 2011Review
- Expression of bone morphogenetic protein-2 in the chondrogenic and ossifying sites of calcific tendinopathy and traumatic tendon injury rat models.Journal of orthopaedic surgery and research · 2009Article
- Chondrocyte phenotype and ectopic ossification in collagenase-induced tendon degeneration.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells.Matrix biology : journal of the International Society for Matrix Biology · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Degeneration of the rotator cuff is often associated with inflammation of the subacromial bursa and focal mineralization of the supraspinatus tendon. Portions of the supraspinatus tendon distant from the insertion site could transform into fibrous cartilage, causing rotator-cuff tears owing to mechanical instability. Indirect evidence is presented to link this pathology to ectopic production and secretion of bioactive bone morphogenetic proteins (BMPs) from sites within the subacromial bursa. Surgically removed specimens of subacromial bursa tissue from patients with chronic tears of the rotator cuff were analyzed by immunohistochemistry and reverse transcription-PCR. Bioactive BMP was detected in bursa extracts by a bioassay based on induction of alkaline phosphatase in the osteogenic/myogenic cell line C2C12. Topical and differential expression of BMP-2/4 and BMP-7 mRNA and protein was found in bursa tissue. The bioassay of C2C12 cells revealed amounts of active BMP high enough to induce osteogenic cell types, and blocking BMP with specific antibodies or soluble BMP receptors Alk-3 and Alk-6 abolished the inductive properties of the extract. Sufficient information was gathered to explain how ectopic expression of BMP might induce tissue transformation into ectopic bone/cartilage and, therefore, promote structural degeneration of the rotator cuff. Early surgical removal of the subacromial bursa might present an option to interrupt disease progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.