ArticleWorld journal of gastroenterology2006
Hyperlipidemia intensifies cerulein-induced acute pancreatitis associated with activation of protein kinase C in rats.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of serum triglyceride concentration on the outcome of acute pancreatitis: systematic review and meta-analysis.Scientific reports · 2018Pooled it
- Potential influence of gut microbiota on the process of hypertriglyceridemia-aggravated acute pancreatitis.World journal of gastroenterology · 2026Review
- Induction of hyperlipidemic pancreatitis by different fatty acids: A narrative review.World journal of gastroenterology · 2025Review
- Comprehensive review on the pathogenesis of hypertriglyceridaemia-associated acute pancreatitis.Annals of medicine · 2023Review
- Hypertriglyceridemia Acute Pancreatitis: Animal Experiment Research.Digestive diseases and sciences · 2022Review
- Hypertriglyceridemia-induced acute pancreatitis in children: A mini-review.Frontiers in pediatrics · 2022Review
- Dysregulated SREBP1c/miR-153 signaling induced by hypertriglyceridemia worsens acute pancreatitis and delays tissue repair.JCI insight · 2021Article
- Large triglyceride-rich lipoproteins in hypertriglyceridemia are associated with the severity of acute pancreatitis in experimental mice.Cell death & disease · 2019Article
- N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide decreases triglyceride levels by downregulation of Apoc3 gene expression in acute hyperlipidemic rat model.Molecular and cellular biochemistry · 2017Article
- Stratified analysis and clinical significance of elevated serum triglyceride levels in early acute pancreatitis: a retrospective study.Lipids in health and disease · 2017Article
- The effect of increased lipoproteins levels on the disposition of vincristine in rat.Lipids in health and disease · 2016Article
- Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis.The American journal of gastroenterology · 2015Observational
- Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis.World journal of gastroenterology · 2015Article
- Issues in hypertriglyceridemic pancreatitis: an update.Journal of clinical gastroenterology · 2014Review
- Breviscapine attenuates acute pancreatitis by inhibiting expression of PKCα and NF-κB in pancreas.World journal of gastroenterology · 2011Article
- Effect of admission hypertriglyceridemia on the episodes of severe acute pancreatitis.World journal of gastroenterology · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of hyperlipidemia on acute pancreatitis (AP) and the possible mechanisms.
methodsRat models of hyperlipidemia and AP were established by Triton WR1339 and cerulein respectively. Human albumin was used to treat AP complicated by hyperlipidemia. In each group, we compared the histological score, volume of ascites, ratio of pancreatic wet/dry weight, serum amylase (AMY) and pancreatic acinar cell apoptosis. The level of protein kinase C (PKC) membrane translocation in pancreatic tissue was detected by Western blot.
resultsIn the hyperlipidemia model established by Triton WR1339, triglyceride (TG) increased remarkably and reached its peak 6 h after injection, and most rats developed mild acute pancreatitis. Histological score, volume of ascites, ratio of wet/dry weight and serum AMY in AP animals with hyperlipidemia were obviously higher than those in AP animals (P < 0.05) and decreased after albumin therapy but not significantly (P > 0.05). Apoptotic cells detected by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) increased in AP animals with hyperlipidemia and did not change distinctly after albumin therapy. PKC membrane translocation level increased in AP animals with hyperlipidemia and decreased remarkably after albumin therapy (P < 0.05).
conclusionHyperlipidemia may induce AP or intensify pancreatic injury. Albumin therapy can not alleviate pancreatic lesion effectively. PKC activation may be one mechanism by which AP is intensified by hyperlipidemia.
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