ArticleWorld journal of gastroenterology2006
Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Predictive Ability of Chinese Visceral Adipose Index for Gastric Intestinal Metaplasia in Korean Adults.Digestive diseases (Basel, Switzerland) · 2026Article
- Immunoexpression of Trefoil Factor 1 in Non-Neoplastic and Neoplastic Canine Gastric Tissues.Animals : an open access journal from MDPI · 2021Article
- Humulene Inhibits Acute Gastric Mucosal Injury by Enhancing Mucosal Integrity.Antioxidants (Basel, Switzerland) · 2021Article
- TFF-1 Functions to Suppress Multiple Phenotypes Associated with Lung Cancer Progression.OncoTargets and therapy · 2021Article
- Deficient Active Transport Activity in Healing Mucosa After Mild Gastric Epithelial Damage.Digestive diseases and sciences · 2020Article
- Disruption of theLaboratory animal research · 2018Article
- TFF1 Promotes EMT-Like Changes through an Auto-Induction Mechanism.International journal of molecular sciences · 2018Article
- Article
- Chronic tamoxifen use is associated with a decreased risk of intestinal metaplasia in human gastric epithelium.Digestive diseases and sciences · 2014Article
- Promoter hypermethylation and downregulation of trefoil factor 2 in human gastric cancer.Oncology letters · 2014Article
- Tests for serum levels of trefoil factor family proteins can improve gastric cancer screening.Gastroenterology · 2011Article
- Article
- Distinctions in gastric cancer gene expression signatures derived from laser capture microdissection versus histologic macrodissection.BMC medical genomics · 2011Article
- Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans.Gastroenterology · 2010Article
- A mouse to human search for plasma proteome changes associated with pancreatic tumor development.PLoS medicine · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
aimTo study the expression of trefoil factor 1 (TFF1) and TFF2 in precancerous condition and gastric cancer and to explore the relationship between TFFs and tumorigenesis, precancerous condition and gastric cancer.
methodsThe expression of TFF1 and TFF2 was immunohistochemically analyzed in paraffin-embedded samples from 140 patients including 35 cases of chronic superficial gastritis (CSG), 35 cases of gastric ulcer (GU), 35 cases of chronic atrophic gastritis (CAG) and 35 cases of gastric cancer (GC).
resultsTFF1 and TFF2 were located in cytoplasm of gastric mucous cells. In CSG, GU, CAG and GC, the level of TFF1 expression had a decreased tendency (P < 0.05). The expression of TFF2 was higher in GU than in CSG, but the difference was not significant. The expression of TFF2 also had a decreased tendency in GU, CAG, and GC (P < 0.05).
conclusionThe reduced expression of TFF1 and TFF2 in precancerous conditions and gastric cancer may be associated with the proliferation and malignant transformation of gastric mucosa. More investigations are needed to explore the mechanism of TFFs and the relationship between TFFs and gastric cancer.
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