ArticleWorld journal of gastroenterology2006
Alterations of seminal and hormonal parameters: An extrahepatic manifestation of HCV infection?
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Temporal trends in sperm count: a systematic review and meta-regression analysis.Human reproduction update · 2017Pooled it
- In vitro fertilization for women infected by hepatitis C virus: a matched case-control study and a systematic literature review.Journal of assisted reproduction and genetics · 2017Pooled it
- From infection to infertility: a review of the role of human papillomavirus-induced oxidative stress on reproductive health and infertility.European journal of medical research · 2025Review
- Unraveling The Impact of Viral Infections on Sperm Genetic Stability: A Scoping Review.International journal of fertility & sterility · 2025Article
- Effect of treatment of chronic hepatitis c virus patients with direct-acting anti-retroviral drugs on semen and hormonal parameters.Clinical and experimental reproductive medicine · 2024Article
- Update on known and emergent viruses affecting human male genital tract and fertility.Basic and clinical andrology · 2024Review
- Viruses and Endocrine Diseases.Microorganisms · 2023Review
- Are sexually transmitted infections associated with male infertility? A systematic review and in-depth evaluation of the evidence and mechanisms of action of 11 pathogens.Arab journal of urology · 2023Review
- Human seminal virome: a panel based on recent literature.Basic and clinical andrology · 2022Review
- SHBG, Bone Mineral Density, and Physical Function Among Injection Drug Users With and Without HIV and HCV.The Journal of clinical endocrinology and metabolism · 2022Article
- The Hepatoprotective and Hepatotoxic Roles of Sex and Sex-Related Hormones.Frontiers in immunology · 2022Review
- Chronic liver diseases and erectile dysfunction.Frontiers in public health · 2022Review
- Viral Infections and Male Infertility: A Comprehensive Review of the Role of Oxidative Stress.Frontiers in reproductive health · 2022Review
- Farnesoid X receptor alpha (FXRα) is a critical actor of the development and pathologies of the male reproductive system.Cellular and molecular life sciences : CMLS · 2019Review
- Impact of hepatitis B virus and hepatitis C virus infection on sperm parameters of infertile men.International journal of reproductive biomedicine · 2019Article
- Testosterone in Men With Chronic Hepatitis C Infection and After Hepatitis C Viral Clearance.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Endocrine disorders associated with hepatitis C virus chronic infection.Reviews in endocrine & metabolic disorders · 2018Review
- [Sexually transmitted infections and male fertility].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Review
- Male infertility: a public health issue caused by sexually transmitted pathogens.Nature reviews. Urology · 2014Review
- Successful fertility restoration after allogeneic hematopoietic stem cell transplantation.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the possible influences of HCV infection and relative antiviral treatment on seminal parameters and reproductive hormonal serum levels.
methodsTen male patients with HCV-related chronic hepatitis and 16 healthy male volunteers were studied. In all subjects seminal parameters (nemaspermic concentration, progressive motility, morphology) and hormonal levels were determined. Seminal parameters and inhibin B, follicle-stimulating hormone, luteinizing hormone, total and free testosterone, estradiol, prolactine in patients were measured after six and twelve months of antiviral combined (interferon+ribavirin) treatment.
resultsPatients before treatment showed a significantly lower nemaspermic motility and morphology as well as lower inhibin B and free testosterone levels than controls. Inhibin B levels in cases were improved six and 12 mo after treatment in five responders (161.9+/-52.8 pg/mL versus 101.7+/-47.0 pg/mL and 143.4+/-46.1 pg/mL versus 95.4+/-55.6 pg/mL, respectively). Hormonal pattern of patients did not significantly change after treatment, with the exception of estradiol levels with an initial reduction and an overall subsequent increment (19.7+/-6.4 pg/mL versus 13.6+/-5.0 pg/mL versus 17.3+/-5.7 pg/mL). However in 1-year responders a significant increment of free testosterone (14.2+/-2.54 pg/mL versus 17.1+/-2.58 pg/mL) occurred. An impairment of nemaspermic morphology occurred, while other seminal parameters did not change significantly during antiviral treatment.
conclusionPatients with HCV infection show worse spermatic parameters than controls, suggesting a possible negative influence of virus on spermatogenesis, with further mild impairment during antiviral treatment. However therapy could improve the spermatic function, as suggested by the increased inhibin B levels and improved hormonal pattern in responders. Further studies are needed to confirm these preliminary intriguing results.
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