ArticleWorld journal of gastroenterology2006
Correlation between TIMP-1 expression and liver fibrosis in two rat liver fibrosis models.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Trial
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- Two sides of the same coin: Non-alcoholic fatty liver disease and atherosclerosis.Vascular pharmacology · 2024Review
- A salivary biomarker panel to detect liver cirrhosis.iScience · 2023Article
- The Role of Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitors in The Attenuation of CClAntioxidants (Basel, Switzerland) · 2023Article
- Association of novel markers of liver disease with neonatal liver disease in premature baboons, Papio sp.PloS one · 2020Article
- Prostate cancer survivors with symptoms of radiation cystitis have elevated fibrotic and vascular proteins in urine.PloS one · 2020Article
- Administration of N-Acyl-Phosphatidylethanolamine Expressing Bacteria to Low Density Lipoprotein ReceptorScientific reports · 2019Article
- Developing an in vitro screening assay platform for evaluation of antifibrotic drugs using precision-cut liver slices.Fibrogenesis & tissue repair · 2015Article
- Article
- Inhibitory effect of antisense oligonucleotide targeting TIMP-2 on immune-induced liver fibrosis.Digestive diseases and sciences · 2010Article
- Oxidative and nitrosative stress and fibrogenic response.Clinics in liver disease · 2008Review
- Dose-Dependent Antifibrotic Effect of Chrysin on Regression of Liver Fibrosis: The Role in Extracellular Matrix Remodeling.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate serum TIMP-1 level and the correlation between TIMP-1 expression and liver fibrosis in immune-induced and CCL4-induced liver fibrosis models in rats.
methodsImmune-induced and CCL4-induced liver fibrosis models were established by dexamethasone (0.01 mg) and CCL4 respectively. Serum TIMP-1 level was detected with ELISA, while histopathological grade of liver biopsy was evaluated. Spearman rank-correlation test was used to analyse the difference of the correlation between the TIMP-1 expression and hepatic fibrosis in the two fibrosis models. Furthermore, in situ hybridization was used to determine the expression difference of TIMP-1 mRNA in the two models.
resultsPositive correlation existed between serum TIMP-1 level of immune induced group and the histopathological stages of fibrosis liver of corresponding rats (Spearman rank-correlation test, r(s) = 0.812, P < 0.05), and the positive in situ hybridization signal of TIMP-1 mRNA was strong. In CCL4-induced liver fibrosis model, the correlation between the serum TIMP-1 level and the severity of hepatic fibrosis was not statistically significant(Spearman rank-correlation test, r(s) = 0.229, P > 0.05). And compared with immune-induced model, the positive in situ hybridization signal of TIMP-1 mRNA was weaker, while the expression variation was higher in hepatic fibrosis of the same severity.
conclusionThe correlations between TIMP-1 expression and liver fibrosis in two rat liver fibrosis models are different. In immune-induced model, serum TIMP-1 level could reflect the severity of liver fibrosis, while in CCL4-induced model, the correlation between the serum TIMP-1 level and the severity of hepatic fibrosis was not statistically significant.
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