ArticleJournal of the Association for Research in Otolaryngology : JARO2006
A biophysical model of the inner hair cell: the contribution of potassium currents to peripheral auditory compression.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 72 citations in OpenAlex.
- The effects of noise-induced hair cell lesions on cochlear electromechanical responses: A computational approach using a biophysical model.International journal for numerical methods in biomedical engineering · 2022Article
- The Analysis of Mammalian Hearing Systems Supports the Hypothesis That Criticality Favors Neuronal Information Representation but Not Computation.Entropy (Basel, Switzerland) · 2022Article
- A comparative study of eight human auditory models of monaural processing.Acta acustica. European Acoustics Association · 2022Article
- A convolutional neural-network framework for modelling auditory sensory cells and synapses.Communications biology · 2021Article
- Adaptation to Noise in Human Speech Recognition Depends on Noise-Level Statistics and Fast Dynamic-Range Compression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Phase Locking of Auditory Nerve Fibers: The Role of Lowpass Filtering by Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Hair cell and neural contributions to the cochlear summating potential.Journal of neurophysiology · 2019Article
- Phase Locking of Auditory-Nerve Fibers Reveals Stereotyped Distortions and an Exponential Transfer Function with a Level-Dependent Slope.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Supra-Threshold Hearing and Fluctuation Profiles: Implications for Sensorineural and Hidden Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2018Review
- The Competition between the Noise and Shear Motion Sensitivity of Cochlear Inner Hair Cell Stereocilia.Biophysical journal · 2018Article
- Analytical and numerical modeling of the hearing system: Advances towards the assessment of hearing damage.Hearing research · 2017Review
- A model of signal processing at the isolated hair cell of the frog semicircular canal.Journal of computational neuroscience · 2017Article
- The role of compression in the simultaneous masker phase effect.The Journal of the Acoustical Society of America · 2016Article
- Ion channel noise can explain firing correlation in auditory nerves.Journal of computational neuroscience · 2016Article
- Functional modeling of the human auditory brainstem response to broadband stimulation.The Journal of the Acoustical Society of America · 2015Article
- Modeling auditory coding: from sound to spikes.Cell and tissue research · 2015Review
- Forward-masking recovery and the assumptions of the temporal masking curve method of inferring cochlear compression.Trends in hearing · 2014Article
- Modelling cochlear mechanics.BioMed research international · 2014Review
- Contralateral efferent reflex effects on threshold and suprathreshold psychoacoustical tuning curves at low and high frequencies.Journal of the Association for Research in Otolaryngology : JARO · 2013Article
- Pitch sensation involves stochastic resonance.Scientific reports · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The term peripheral auditory compression refers to the fact that the whole range of audible sound pressure levels is mapped into a narrower range of auditory nerve responses. Peripheral compression is the by-product of independent compressive processes occurring at the level of the basilar membrane, the inner hair cell (IHC), and the auditory nerve synapse. Here, an electrical-circuit equivalent of an IHC is used to look into the compression contributed by the IHC. The model includes a mechanically driven transducer potassium (K(+)) conductance and two time- and voltage-dependent basolateral K(+) conductances: one with fast and one with slow kinetics. Special attention is paid to faithfully implement the activation kinetics of these basolateral conductances. Optimum model parameters are provided to account for previously reported in vitro observations that demonstrate the compression associated with the gating of the transducer and of the basolateral channels. Without having to readjust its parameters, the model also accounts for the in vivo nonlinear IHC transfer characteristics. Model simulations are then used to investigate the relative contribution of the transducer and basolateral K(+) currents to the nonlinear IHC input/output functions in vivo. The simulations suggest that the voltage-dependent activation of the basolateral currents compresses the DC potential for stereocilia displacements above approximately 5 nm. The degree of compression exceeds 2-to-1 and is similar for all stimulation frequencies. The AC potential is compressed in a similar way, but only for frequencies below 800 Hz. The simulations further suggest that the nonlinear gating of the transducer current is responsible for the expansive growth of the DC potential with increasing sound level (slope of 2 dB/dB) at low sound pressure levels.
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