ArticleMolecular and cellular biochemistry2006
Activity and expression of ecto-5'-nucleotidase/CD73 are increased by thyroid hormones in vascular smooth muscle cells.
Article in Molecular and cellular biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Cell Surface Markers of Mesenchymal Stem Cells: Current Knowledge and Advances in Characterization Technologies.Life (Basel, Switzerland) · 2025Review
- Brain hypothyroidism silences the immune response of microglia in Alzheimer's disease animal model.Science advances · 2024Article
- Thyroid Hormone Resistance Syndrome: From Molecular Mechanisms to Its Potential Contribution to Hypertension.Cureus · 2023Review
- Clinical features and long-term survival in idiopathic pulmonary arterial hypertension with thyroid dysfunction: insights from a national multicentre prospective study.ERJ open research · 2023Article
- Is the regulation by miRNAs of NTPDase1 and ecto-5'-nucleotidase genes involved with the different profiles of breast cancer subtypes?Purinergic signalling · 2022Article
- The Role of Thyroid Disorders, Obesity, Diabetes Mellitus and Estrogen Exposure as Potential Modifiers for Pulmonary Hypertension.Journal of clinical medicine · 2022Review
- Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Targeting Novel Sodium Iodide Symporter Interactors ADP-Ribosylation Factor 4 and Valosin-Containing Protein Enhances Radioiodine Uptake.Cancer research · 2020Article
- The role of thyroid hormone in metabolism and metabolic syndrome.Therapeutic advances in endocrinology and metabolism · 2020Review
- Inhibition of the adenosinergic pathway: the indispensable part of oncological therapy in the future.Purinergic signalling · 2019Review
- Coding Cell Identity of Human Skeletal Muscle Progenitor Cells Using Cell Surface Markers: Current Status and Remaining Challenges for Characterization and Isolation.Frontiers in cell and developmental biology · 2019Review
- Extracellular ATP is Differentially Metabolized on Papillary Thyroid Carcinoma Cells Surface in Comparison to Normal Cells.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2018Article
- Recombinant soluble apyrase APT102 inhibits thrombosis and intimal hyperplasia in vein grafts without adversely affecting hemostasis or re-endothelialization.Journal of thrombosis and haemostasis : JTH · 2017Article
- Pulmonary hypertension in thyroid diseases.Endocrine · 2016Review
- Purinergic signalling in endocrine organs.Purinergic signalling · 2014Review
- The roles of CD73 in cancer.BioMed research international · 2014Review
- Commonly used mesenchymal stem cell markers and tracking labels: Limitations and challenges.Histology and histopathology · 2013Review
- Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes.Cardiovascular research · 2010Article
- Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development.Journal of leukocyte biology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular nucleotides ATP, ADP, AMP and adenosine are well known signaling molecules of the cardiovascular system that are involved in several physiological processes: cell proliferation, platelet aggregation, inflammatory processes and vascular tonus. The levels of these molecules are controlled by ecto-NTPDases and ecto-5'-nucleotidase/CD73 (ecto-5'-NT/CD73) actions, which are responsible for the complete ATP degradation to adenosine. The thyroid hormones, thyroxine (T(4)) and triiodothyronine (T(3)), play important roles in the vascular system promoting vasodilatation. Here we investigated the influence of thyroid hormones on the enzyme cascade that catalyzes the interconversion of purine nucleotides in vascular smooth muscle cells (VSMC). Exposure of VSMCs to 50nM T(3) or T(4) did not change ATP and ADP hydrolysis significantly. However, the same treatment caused an increase of 75% in AMP hydrolysis, which was time-dependent but dose-independent. Moreover, T(3) treatment significantly increased ecto-5'-NT/CD73 mRNA expression, which suggests a genomic effect of this hormone upon ecto-5'-NT/CD73. In addition to the importance of the ecto-5'-NT in cell proliferation and differentiation, its overexpression could result in higher extracellular levels of adenosine, an important local vasodilatator molecule.
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