ArticleNucleic acids research2006
Yeast Protein Interactome topology provides framework for coordinated-functionality.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Biomarker development in the precision medicine era: lung cancer as a case study.Nature reviews. Cancer · 2016Review
- Large scale of human duplicate genes divergence.Journal of molecular evolution · 2012Article
- Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation.PLoS computational biology · 2011Article
- Modeling and analysis of retinoic acid induced differentiation of uncommitted precursor cells.Integrative biology : quantitative biosciences from nano to macro · 2011Article
- Coordinated modular functionality and prognostic potential of a heart failure biomarker-driven interaction network.BMC systems biology · 2010Article
- POLAR MAPPER: a computational tool for integrated visualization of protein interaction networks and mRNA expression data.Journal of the Royal Society, Interface · 2009Article
- Functional organization of the yeast proteome by a yeast interactome map.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Topological properties of protein interaction networks from a structural perspective.Biochemical Society transactions · 2008Review
- Age-dependent evolution of the yeast protein interaction network suggests a limited role of gene duplication and divergence.PLoS computational biology · 2008Article
- Discovering functional interaction patterns in protein-protein interaction networks.BMC bioinformatics · 2008Article
- AtPID: Arabidopsis thaliana protein interactome database--an integrative platform for plant systems biology.Nucleic acids research · 2008Article
- In search of the biological significance of modular structures in protein networks.PLoS computational biology · 2007Article
- Molecular chaperones: the modular evolution of cellular networks.Journal of biosciences · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The architecture of the network of protein-protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures, betweenness centrality and 'Q-modularity'. The yeast interactome is characterized by well-defined topological modules connected via a small number of inter-module protein interactions. Should such topological inter-module connections turn out to constitute a form of functional coordination between the modules, we speculate that this coordination is occurring typically in a pairwise fashion, rather than by way of high-degree hub proteins responsible for coordinating multiple modules. The unique non-hub-centric hierarchical organization of the interactome is not reproduced by gene duplication-and-divergence stochastic growth models that disregard global selective pressures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.