ArticleNucleic acids research2006
Genome prediction of PhoB regulated promoters in Sinorhizobium meliloti and twelve proteobacteria.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 120 citations in OpenAlex.
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- Characteristics of plant growth-promoting rhizobacteria SCPG-7 and its effect on the growth of Capsicum annuum L.Environmental science and pollution research international · 2021Article
- Arginine-Rich Small Proteins with a Domain of Unknown Function, DUF1127, Play a Role in Phosphate and Carbon Metabolism of Agrobacterium tumefaciens.Journal of bacteriology · 2020Article
- A Novel OmpR-Type Response Regulator Controls Multiple Stages of theFrontiers in microbiology · 2020Article
- Ornithine Lipids inFrontiers in molecular biosciences · 2020Article
- Differential Effects of Varying Concentrations of Phosphorus, Iron, and Nitrogen in NFrontiers in microbiology · 2020Article
- Regulation ofJournal of bacteriology · 2019Article
- Galactitol catabolism in Sinorhizobium meliloti is dependent on a chromosomally encoded sorbitol dehydrogenase and a pSymB-encoded operon necessary for tagatose catabolism.Molecular genetics and genomics : MGG · 2019Article
- Inorganic Polyphosphate Accumulation in Escherichia coli Is Regulated by DksA but Not by (p)ppGpp.Journal of bacteriology · 2019Article
- The Role of Iron in the P-Acquisition Mechanisms of the Unicellular NFrontiers in microbiology · 2019Article
- Genome-wide identification of genes directly regulated by ChvI and a consensus sequence for ChvI binding in Sinorhizobium meliloti.Molecular microbiology · 2018Article
- An Iterative, Synthetic Approach To Engineer a High-Performance PhoB-Specific Reporter.Applied and environmental microbiology · 2018Article
- Mutations in Escherichia coli Polyphosphate Kinase That Lead to Dramatically IncreasedJournal of bacteriology · 2018Article
- Characteristics of Organic Acid Secretion Associated with the Interaction betweenBioMed research international · 2018Article
- Altered Regulation of the Diguanylate Cyclase YaiC Reduces Production of Type 1 Fimbriae in a Pst Mutant of Uropathogenic Escherichia coli CFT073.Journal of bacteriology · 2017Article
- PhoU Allows Rapid Adaptation to High Phosphate Concentrations by Modulating PstSCAB Transport Rate in Sinorhizobium meliloti.Journal of bacteriology · 2017Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In proteobacteria, genes whose expression is modulated in response to the external concentration of inorganic phosphate are often regulated by the PhoB protein which binds to a conserved motif (Pho box) within their promoter regions. Using a position weight matrix algorithm derived from known Pho box sequences, we identified 96 putative Pho regulon members whose promoter regions contained one or more Pho boxs in the Sinorhizobium meliloti genome. Expression of these genes was examined through assays of reporter gene fusions and through comparison with published microarray data. Of 96 genes, 31 were induced and 3 were repressed by Pi starvation in a PhoB dependent manner. Novel Pho regulon members included several genes of unknown function. Comparative analysis across 12 proteobacterial genomes revealed highly conserved Pho regulon members including genes involved in Pi metabolism (pstS, phnC and ppdK). Genes with no obvious association with Pi metabolism were predicted to be Pho regulon members in S.meliloti and multiple organisms. These included smc01605 and smc04317 which are annotated as substrate binding proteins of iron transporters and katA encoding catalase. This data suggests that the Pho regulon overlaps and interacts with several other control circuits, such as the oxidative stress response and iron homeostasis.
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