ArticleProceedings of the National Academy of Sciences of the United States of America2006
Histamine signaling through the H(2) receptor in the Peyer's patch is important for controlling Yersinia enterocolitica infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 56 citations in OpenAlex.
- Exploring the Gut-Brain Connection: Are Probiotics the Next Frontier in Alzheimer's Disease Treatment?Probiotics and antimicrobial proteins · 2026Review
- YopP modulates bacterial virulence and systemic dissemination in Peyer´s patches during murine Yersinia enterocolitica infection.Medical microbiology and immunology · 2025Article
- Deficiency of Lactoferrin aggravates lipopolysaccharide-induced acute inflammation via recruitment macrophage in mice.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Microbiota-Gut-Brain Axis: Pathophysiological Mechanism in Neuropsychiatric Disorders.Advances in experimental medicine and biology · 2023Article
- Shedding light on biological sex differences and microbiota-gut-brain axis: a comprehensive review of its roles in neuropsychiatric disorders.Biology of sex differences · 2022Review
- Yersiniabactin contributes to overcoming zinc restriction duringProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Gut Biofactory-Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review.Nutrients · 2020Article
- Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection.PLoS pathogens · 2020Article
- Distinct roles of histamine H1- and H2-receptor signaling pathways in inflammation-associated colonic tumorigenesis.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- The Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders: Pathophysiological Mechanisms and Novel Treatments.Current neuropharmacology · 2018Article
- Tissue dual RNA-seq allows fast discovery of infection-specific functions and riboregulators shaping host-pathogen transcriptomes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- May the Force Be With You: The Light and Dark Sides of the Microbiota-Gut-Brain Axis in Neuropsychiatry.CNS drugs · 2016Review
- Altered esophageal histamine receptor expression in Eosinophilic Esophagitis (EoE): implications on disease pathogenesis.PloS one · 2015Article
- Role of innate immunity and altered intestinal motility in LPS- and MnCl2-induced intestinal intussusception in mice.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Murine neonates infected with Yersinia enterocolitica develop rapid and robust proinflammatory responses in intestinal lymphoid tissues.Infection and immunity · 2014Article
- Article
- Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes.Genes and immunity · 2012Article
- Mycoplasma pneumoniae CARDS toxin induces pulmonary eosinophilic and lymphocytic inflammation.American journal of respiratory cell and molecular biology · 2012Article
- A metabolic network approach for the identification and prioritization of antimicrobial drug targets.Trends in microbiology · 2012Review
- Mitogen-activated protein kinase-dependent interleukin-1α intracrine signaling is modulated by YopP during Yersinia enterocolitica infection.Infection and immunity · 2012Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Enteric pathogens such as Yersinia enterocolitica readily colonize and induce disease within the lymphatic tissues of the small intestine. To gain a comprehensive view of the host response to pathogens within these tissues, we determined the transcriptional profiles of intestinal lymphatic tissue infected with Y. enterocolitica. Expression analysis using Affymetrix GeneChips revealed a complex host response in the Peyer's patches and mesenteric lymph nodes after oral infection with Y. enterocolitica. Interestingly, histidine decarboxylase (Hdc) was significantly up-regulated in response to Y. enterocolitica infection. HDC is the enzyme solely responsible for the production of the biogenic amine histamine. Although histamine is well known for its role in allergy and for its effects on immunity and inflammation, little is known about its role or specific histamine receptors during the host response to bacterial infection. In this study, we provide evidence that histamine signaling through the histamine H(2) but not the H(1) receptor is important for controlling Y. enterocolitica infection within the Peyer's patches and mesenteric lymph nodes of mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.