ReviewPharmaceutical research2006
Metabonomics techniques and applications to pharmaceutical research & development.
Review in Pharmaceutical research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed.
- Increasing carbohydrates or nitrogenous compounds by cecal infusion leads to an opposite influence on colonic microbiota and host metabolism in a pig model.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Stage-specific metabolic allocation: nutrient investment strategies duringFrontiers in nutrition · 2025Article
- Effects of Hypoxia and Reoxygenation on Metabolic Profiles of Cardiomyocytes.Cell biochemistry and biophysics · 2024Article
- Article
- Metabolomic Profiles of Multidrug-ResistantAnimals : an open access journal from MDPI · 2022Article
- Untargeted Metabolomics Sensitively Differentiates Gut Bacterial Species in Single Culture and Co-Culture Systems.ACS omega · 2022Article
- Pharmacometabolomics by NMR in Oncology: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Influence of pregnancy and non-fasting conditions on the plasma metabolome in a rat prenatal toxicity study.Archives of toxicology · 2021Article
- You Are What You Eat: Application of Metabolomics Approaches to Advance Nutrition Research.Foods (Basel, Switzerland) · 2021Review
- Metabolic Profile of Patients with Severe Endometriosis: a Prospective Experimental Study.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- An Early Stage Researcher's Primer on Systems Medicine Terminology.Network and systems medicine · 2021Review
- In vivo toxicometabolomics reveals multi-organ and urine metabolic changes in mice upon acute exposure to human-relevant doses of 3,4-methylenedioxypyrovalerone (MDPV).Archives of toxicology · 2021Article
- Radioprotection and Radiomitigation: From the Bench to Clinical Practice.Biomedicines · 2020Review
- Discriminating aspects of global metabolism of neonatal cardiomyocytes from wild type and KO-CSRP3 rats using proton magnetic resonance spectroscopy of culture media samples.In vitro cellular & developmental biology. Animal · 2020Article
- A novel critical control point and chemical marker identification method for the multi-step process control of herbal medicinesRSC advances · 2020Article
- Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease.International journal of molecular medicine · 2020Article
- A Comparative Study of Rat UrineBiology · 2020Article
- A Metabolomic Approach for the In Vivo Study of Gold Nanospheres and Nanostars after a Single-Dose Intravenous Administration to Wistar Rats.Nanomaterials (Basel, Switzerland) · 2019Article
- Salivary and urinary metabolome analysis for pre-puberty-related biomarkers identification in porcine.Animal : an international journal of animal bioscience · 2019Article
- UPLC-HRMS-Based Plasma Metabolomic Profiling of Novel Biomarkers by Treatment with KDZI in Cerebral Ischemia Reperfusion Rats.Molecules (Basel, Switzerland) · 2018Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review, the background to the approach known as metabonomics is provided, giving a brief historical perspective and summarizing the analytical and statistical techniques used. Some of the major applications of metabonomics relevant to pharmaceutical Research & Development are then reviewed including the study of various influences on metabolism, such as diet, lifestyle, and other environmental factors. The applications of metabonomics in drug safety studies are explained with special reference to the aims and achievements of the Consortium for Metabonomic Toxicology. Next, the role that metabonomics might have in disease diagnosis and therapy monitoring is provided with some examples, and the concept of pharmacometabonomics as a way of predicting an individual's response to treatment is highlighted. Some discussion is given on the strengths and weaknesses, opportunities of, and threats to metabonomics.
Indexed as
Identifiers
16715371What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.