ArticlePflugers Archiv : European journal of physiology2006
Successful implantation of intravenously administered stem cells correlates with severity of inflammation in murine myocarditis.
Article in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Interaction of head and neck squamous cell carcinoma cells and mesenchymal stem cells under hypoxia and normoxia.Oncology letters · 2020Article
- Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function.Molecular therapy. Methods & clinical development · 2020Article
- A comparative study of the influence of two types of PHEMA stents on the differentiation of ASCs to myocardial cells.Molecular medicine reports · 2017Article
- Toxicological effect of TiO2 nanoparticle-induced myocarditis in mice.Nanoscale research letters · 2015Article
- Therapeutic application of adipose derived stem cells in acute myocardial infarction: lessons from animal models.Stem cell reviews and reports · 2014Review
- MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation.Cancer research · 2012Article
- Effects of histocompatibility and host immune responses on the tumorigenicity of pluripotent stem cells.Seminars in immunopathology · 2011Review
- Stem cell-based therapies in ischemic heart diseases: a focus on aspects of microcirculation and inflammation.Basic research in cardiology · 2011Review
- Effects of orthopedic polymer particles on chemotaxis of macrophages and mesenchymal stem cells.Journal of biomedical materials research. Part A · 2010Article
- Coronary vessel development and insight towards neovascular therapy.International journal of experimental pathology · 2009Review
- Calcium and cyclic nucleotides affect TNF-alpha-induced stem cell migration.Biochemical and biophysical research communications · 2009Article
- Efficient gene delivery to myocardium with ultrasound targeted microbubble destruction and polyethylenimine.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2008Article
- Accumulation of fibronectin in the heart after myocardial infarction: a putative stimulator of adhesion and proliferation of adipose-derived stem cells.Cell and tissue research · 2008Article
- Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells.Gene therapy · 2008Review
- Homing and differentiation of mesenchymal stem cells delivered intravenously to ischemic myocardium in vivo: a time-series study.Pflugers Archiv : European journal of physiology · 2006Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was designed to determine whether cardiac inflammation is important for the successful homing of stem cells to the heart after intravenous injection in a murine myocarditis model. Male Bagg albino/c mice were infected with encephalomyocarditis virus (EMCV) to produce myocarditis. Subgroups of mice received single injections by tail vein of embryonic stem cells (ESCs) transfected with green fluorescent protein (GFP) as a marker at days 3, 14, or 60 after infection; other subgroups without stem cell injections were killed at each of these time points to assess the degree of inflammation present. The surviving mice were killed at day 90 after virus infection and hemodynamics, gross pathology, histology, and inflammatory cytokine production in the hearts were measured. Our results indicate that myocardial inflammation was most severe and cytokine production highest at day 14 after EMCV inoculation, and in particular, was strongly positive for interleukin 6. Mice receiving intravenous ESC injections on day 14 after EMCV inoculation showed the largest number of GFP-positive cells at the time of death and the greatest functional improvement compared to uninfected controls without inflammation. We conclude that factors released from myocardium during inflammation are important for enhancing the homing, migration, and implantation of systemically infused stem cells.
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