ArticleOncogene2006
A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
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- The tumor suppressor FAT1 controls YAP/TAZ protein degradation and tumor cell proliferation through E3 ligase MIB2.PloS one · 2025Article
- SOX17 expression in ovarian clear cell carcinoma.Journal of ovarian research · 2024Article
- SOX17 expression in tumor-penetrating vessels in relation to CD8Thoracic cancer · 2024Article
- Implication of IZUMO2 in the cell-in-cell phenomenon: A potential therapeutic target for triple-negative breast cancer.Thoracic cancer · 2024Article
- An adiponectin paralog protein, CTRP6 decreased the proliferation and invasion activity of oral squamous cell carcinoma cells: possible interaction with laminin receptor pathway.Molecular biology reports · 2019Article
- CD151 confers metastatic potential to clear cell sarcoma of the soft tissue in animal model.Oncology letters · 2019Article
- Organ-confined plasmacytoid urothelial carcinoma: implication of the lack of expression of the receptor tyrosine kinase MET.International journal of clinical and experimental pathology · 2018Article
- Early Onset Multiple Primary Tumors in Atypical Presentation of Cowden Syndrome Identified by Whole-Exome-Sequencing.Frontiers in genetics · 2018Article
- Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer.Scientific reports · 2016Article
- Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.Oncotarget · 2016Article
- Epigenetic regulation in human melanoma: past and future.Epigenetics · 2015Review
- Article
- The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling.Oncotarget · 2014Article
- Lysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein.Journal of virology · 2014Article
- Matrix metalloproteinase-11 overexpressed in lobular carcinoma cells of the breast promotes anoikis resistance.Virchows Archiv : an international journal of pathology · 2011Article
- Notch signalling in solid tumours: a little bit of everything but not all the time.Nature reviews. Cancer · 2011Review
- Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.International journal of experimental pathology · 2011Article
- Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.Neuro-oncology · 2010Article
- Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies.Journal of translational medicine · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletrophin (mindbomb homolog 2 (MIB2)) is a RING (Really Interesting New Gene) finger-dependent ubiquitin ligase, which targets the intracellular region of Notch ligands. A previous immunohistochemical study demonstrated that skeletrophin was downregulated in many melanomas. In the present study, we have identified a promoter region of skeletrophin on a CpG island and detected aberrant methylation of this region in six of 31 invasive melanomas, but in none of 25 benign nevi or five non-invasive superficial spreading melanomas. Subsequently, we found that a zinc-finger transcriptional factor Snail, which is overexpressed in many melanoma cells, repressed the skeletrophin promoter activity via an E-box-related element and was involved in downregulation of skeletrophin. An activator protein-2, which has a tumor suppressor-like role in melanoma, increased skeletrophin expression. Interestingly, exogenously expressed skeletrophin reduced melanoma cell invasion in vitro and in vivo. Colony formation in soft agar was also reduced in a RING motif-dependent manner, without affecting cell growth. We also found that skeletrophin downregulated transcription of the Met oncogene, which encodes the hepatocyte growth factor receptor and plays a role in the determination of the invasive phenotype of many malignant tumors. Finally, exogenously expressed skeletrophin, but not its RING mutant, increased transcription of Hes1 gene, a downstream effector of Notch pathway in melanoma cells. The present findings indicate that skeletrophin might be a novel suppressor factor for melanoma invasion.
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