ArticleInfection and immunity2006
Variation in the presence of neuraminidase genes among Streptococcus pneumoniae isolates with identical sequence types.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Virulence factors and therapeutic methods ofVirulence · 2025Review
- The metabolic, microbial and immunological demands of pneumococcal colonisation.PLoS pathogens · 2025Review
- Neuraminidase-mediated enhancement ofmBio · 2025Article
- Impedimetric Characterization of NanA Structural Domains Activity on Sialoside-Containing Interfaces.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Streptococcus pneumoniae serotype 19A from carriers and invasive disease: virulence gene profile and pathogenicity in a Galleria mellonella model.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Role ofFrontiers in cellular and infection microbiology · 2023Review
- The Contribution of Viral Proteins to the Synergy of Influenza and Bacterial Co-Infection.Viruses · 2022Review
- Streptococcus Pneumoniae-Associated Hemolytic Uremic Syndrome in the Era of Pneumococcal Vaccine.Pathogens (Basel, Switzerland) · 2021Review
- Neuraminidase B controls neuraminidase A-dependent mucus production and evasion.PLoS pathogens · 2021Article
- Editorial: Otitis Media Genomics and the Middle Ear Microbiome.Frontiers in genetics · 2021Article
- Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria.The Journal of biological chemistry · 2020Article
- New insights into the pathogenesis of Streptococcus pneumoniae-associated hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2020Review
- Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection.Journal of innate immunity · 2020Review
- Article
- Pathogenicity and Virulence ofInternational journal of molecular sciences · 2019Review
- Comparative studies of catalytic pathways for Streptococcus pneumoniae sialidases NanA, NanB and NanC.Scientific reports · 2019Article
- Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood.Frontiers in cellular and infection microbiology · 2019Article
- Catalytic mechanism of type C sialidase from Streptococcus pneumoniae: from covalent intermediate to final product.Journal of molecular modeling · 2018Article
- Streptococcus pneumoniae Sialidase SpNanB-Catalyzed One-Pot Multienzyme (OPME) Synthesis of 2,7-Anhydro-Sialic Acids as Selective Sialidase Inhibitors.The Journal of organic chemistry · 2018Article
- Sialidase-catalyzed one-pot multienzyme (OPME) synthesis of sialidase transition-state analogue inhibitors.ACS catalysis · 2018Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Streptococcus pneumoniae frequently colonizes the upper respiratory tract of young children and is an important cause of otitis media and invasive disease. Carriage is more common than disease, yet the genetic factors that predispose a given clone for disease are not known. The relationship between capsule type, genetic background, and virulence is complex, and important questions remain regarding how pneumococcal clones differ in their ability to cause disease. Pneumococcal neuraminidase cleaves sialic acid-containing substrates and is thought to be important for pneumococcal virulence. We describe the distribution of multilocus sequence types (ST), capsule type, and neuraminidase genes among 342 carriage, middle ear, blood, and cerebrospinal fluid (CSF) pneumococcal strains from young children. We found 149 STs among our S. pneumoniae isolates. nanA was present in all strains, while nanB and nanC were present in 96% and 51% of isolates, respectively. The distribution of nanC varied among the strain collections from different tissue sources (P = 0.03). The prevalence of nanC was 1.41 (95% confidence interval, 1.11, 1.79) times higher among CSF isolates than among carriage isolates. We identified isolates of the same ST that differed in the presence of nanB and nanC. These studies demonstrate that virulence determinants, other than capsule loci, vary among strains of identical ST. Our studies suggest that the presence of nanC may be important for tissue-specific virulence. Studies that both incorporate MLST and take into account additional virulence determinants will provide a greater understanding of the pneumococcal virulence potential.
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