ArticleTheoretical population biology2006
Improving estimates of the basic reproductive ratio: using both the mean and the dispersal of transition times.
Article in Theoretical population biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Quantifying the treatment efficacy of reverse transcriptase inhibitors: new analyses of clinical data based on within-host modeling.BMC public health · 2009Trial
- Rnaught: a web tool for estimating the basic reproduction number.BMC global and public health · 2025Article
- Mitigating bias in estimating epidemic severity due to heterogeneity of epidemic onset and data aggregation.Annals of epidemiology · 2022Article
- Effects of memory on the shapes of simple outbreak trees.Scientific reports · 2016Article
- The basic reproduction number as a predictor for epidemic outbreaks in temporal networks.PloS one · 2015Article
- A Bayesian inferential approach to quantify the transmission intensity of disease outbreak.Computational and mathematical methods in medicine · 2015Article
- The failure of R0.Computational and mathematical methods in medicine · 2011Review
- Resolving the impact of waiting time distributions on the persistence of measles.Journal of the Royal Society, Interface · 2010Article
- Correcting the actual reproduction number: a simple method to estimate R(0) from early epidemic growth data.International journal of environmental research and public health · 2010Article
- Transmission dynamics and prospects for the elimination of canine rabies.PLoS biology · 2009Article
- Noise, nonlinearity and seasonality: the epidemics of whooping cough revisited.Journal of the Royal Society, Interface · 2008Article
- Model-consistent estimation of the basic reproduction number from the incidence of an emerging infection.Journal of mathematical biology · 2007Article
- Modelling the evolution of drug resistance in the presence of antiviral drugs.BMC public health · 2007Article
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No grant is acknowledged in the PubMed record.
Abstract
In both within-host and epidemiological models of pathogen dynamics, the basic reproductive ratio, R(0), is a powerful tool for gauging the risk associated with an emerging pathogen, or for estimating the magnitude of required control measures. Techniques for estimating R(0), either from incidence data or in-host clinical measures, often rely on estimates of mean transition times, that is, the mean time before recovery, death or quarantine occurs. In many cases, however, either data or intuition may provide additional information about the dispersal of these transition times about the mean, even if the precise form of the underlying probability distribution remains unknown. For example, we may know that recovery typically occurs within a few days of the mean recovery time. In this paper we elucidate common situations in which R(0) is sensitive to the dispersal of transition times about their respective means. We then provide simple correction factors that may be applied to improve estimates of R(0) when not only the mean but also the standard deviation of transition times out of the infectious state can be estimated.
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