ArticleImmunity & ageing : I & A2006
A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis.
Article in Immunity & ageing : I & A, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy.Signal transduction and targeted therapy · 2026Review
- Multimodal analysis of molecular remodeling in aging spleen identified global and cell type specific changes.bioRxiv : the preprint server for biology · 2026Article
- The Pathogenic Role of T Cell Metabolism and its Effect on Immune Senescence in Autoimmune Diseases and Infection.Clinical reviews in allergy & immunology · 2025Review
- Relationship between inflammatory markers and long-term prognosis in ICU patients with acute non-ST-segment elevation myocardial infarction.Frontiers in cardiovascular medicine · 2025Article
- Association of lymphocyte count and serum albumin concentration with telomere length in Chinese sanitation workers.PloS one · 2024Article
- Phenomic Microglia Diversity as a Druggable Target in the Hippocampus in Neurodegenerative Diseases.International journal of molecular sciences · 2023Review
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- Dynamic bioinspired coculture model for probing ERScience advances · 2023Article
- The association between systemic inflammatory response index and new-onset atrial fibrillation in patients with ST-elevated myocardial infarction treated with percutaneous coronary intervention.BMC cardiovascular disorders · 2022Article
- Old plasma dilution reduces human biological age: a clinical study.GeroScience · 2022Article
- The mechanistic role of neutrophil lymphocyte ratio perturbations in the leading non communicable lifestyle diseases.F1000Research · 2022Review
- The Relationship of Low-Density-Lipoprotein to Lymphocyte Ratio with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2022Article
- Relationship Between Immunoinflammation and Coronary Physiology Evaluated by Quantitative Flow Ratio in Patients With Coronary Artery Disease.Frontiers in cardiovascular medicine · 2021Article
- Prognostic Utility of the Combination of Platelet Count with Neutrophil-to-Lymphocyte Ratio in Aged Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention.Emergency medicine international · 2021Article
- The Emerging Role of the Interplay Among Astrocytes, Microglia, and Neurons in the Hippocampus in Health and Disease.Frontiers in aging neuroscience · 2021Review
- Low serum lymphocyte level is associated with poor exercise capacity and quality of life in chronic obstructive pulmonary disease.Scientific reports · 2020Article
- Peroxisomes in host defense.PLoS pathogens · 2020Article
- Association between primary immunodeficiency and asthma exacerbation in adult asthmatics.The Korean journal of internal medicine · 2020Article
- An Overview on the Differential Interplay Among Neurons-Astrocytes-Microglia in CA1 and CA3 Hippocampus in Hypoxia/Ischemia.Frontiers in cellular neuroscience · 2020Review
- Exercise and Inflammation.Antioxidants (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In this brief review, we will present evidence for the role of increased apoptosis in immunodeficiency and paradoxical increased inflammation associated with human aging. In particular, a role of apoptotic cells in failure to generate anti-inflammatory responses and directly activating inflammatory responses will be discussed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.