ArticleInternational journal of legal medicine2007
Mast cell tryptase in postmortem serum-reference values and confounders.
Article in International journal of legal medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Diagnostic role of serum tryptase in anaphylactic deaths in forensic medicine: a systematic review and meta-analysis.Forensic science, medicine, and pathology · 2018Pooled it
- Markedly Increased Diamine Oxidase During Acute Anaphylaxis Is Associated With an Underlying Clonal Mast Cell Disorder.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- An Insight into Kounis Syndrome: Bridging Clinical Knowledge with Forensic Perspectives.Life (Basel, Switzerland) · 2024Review
- Postmortem Biochemistry and Immunohistochemistry in Anaphylactic Death Due to Hymenoptera Sting: A Forensic Case Report.International journal of environmental research and public health · 2023Article
- Anaphylactic Death: A New Forensic Workflow for Diagnosis.Healthcare (Basel, Switzerland) · 2021Article
- "Diagnostic role of serum tryptase in anaphylactic deaths in forensic medicine: a systematic review and meta-analysis" should be re-calibrated and re-edited.Forensic science, medicine, and pathology · 2019Article
- The effects of different sampling techniques on peripheral post mortem tryptase levels: a recommended sampling method.International journal of legal medicine · 2019Article
- Biomarkers in Human Anaphylaxis: A Critical Appraisal of Current Evidence and Perspectives.Frontiers in immunology · 2019Review
- Intra-individual alterations of serum markers routinely used in forensic pathology depending on increasing post-mortem interval.Scientific reports · 2018Article
- Vaccination and anaphylaxis: a forensic perspective.Croatian medical journal · 2017Review
- Deaths from bee stings: a report of three cases from Pretoria, South Africa.Forensic science, medicine, and pathology · 2016Article
- Are mast cells implicated in asphyxia?International journal of legal medicine · 2016Article
- Fatal laryngeal angioedema: a case report and a workup of angioedema in a forensic setting.Forensic science, medicine, and pathology · 2015Article
- Amniotic fluid embolism pathophysiology suggests the new diagnostic armamentarium: β-tryptase and complement fractions C3-C4 are the indispensable working tools.International journal of molecular sciences · 2015Review
- Splenic hypereosinophilia in anaphylaxis-related death: different assessments depending on different types of allergens?International journal of legal medicine · 2015Article
- Allergic reactions following contrast material administration: nomenclature, classification, and mechanisms.International journal of legal medicine · 2014Review
- Postmortem chemistry update part II.International journal of legal medicine · 2012Review
- Pathogenic role of cardiac mast cell activation/degranulation,TNF-alpha, and cell death in acute drug-related fatalities.Vascular health and risk management · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the effects of some factors suspected of inducing spuriously increased tryptase concentrations, specifically sampling site, conjunctival petechial bleeding and prone position at the time of death as indicators of premortem asphyxia, and resuscitation efforts by external cardiac massage. Tryptase was measured in blood from the femoral vein in 60 deaths: 39 control cases who died rapidly (within minutes) from natural causes (sudden cardiac death and acute aortic dissection), 16 with death caused by prolonged asphyxia (traumatic compression of the chest and suffocation due to body position or smothering), and five anaphylactic deaths. In 44 of these cases, tryptase was measured in both heart and femoral blood. Mast cell tryptase was analyzed with a commercial FEIA method (Pharmacia Diagnostics AB, Uppsala, Sweden) measuring both alpha- and beta-tryptase. Assuming that tryptase values in the control group were gamma distributed, we calculated the upper normal limits for tryptase concentrations in femoral blood. It was found that 95% of the controls had values below 44.3 mug/l (femoral blood), SD 5.27 mug/l. All but one of the anaphylactic deaths had tryptase concentrations exceeding that limit. Tryptase was significantly elevated in femoral blood from anaphylactic deaths (p<0.007), compared with the controls. Also, in the cases where death had occurred due to asphyxia tryptase was elevated in femoral blood (p<0.04). A significant difference in tryptase concentrations was seen between blood from the heart and the femoral vessels (p<0.02) in the whole material (n=44). Tryptase concentrations in femoral blood were not influenced by prone position at death, or resuscitation efforts. It is concluded that asphyxia premortem seems to affect tryptase concentrations, that postmortem tryptase measurements should be done in serum from femoral blood, and that the normal upper limit, covering 95%, is 44.3 microg/l.
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