Trial reportPsychopharmacology2006
The effect of acute tryptophan depletion on the BOLD response during performance monitoring and response inhibition in healthy male volunteers.
Trial report in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Neuroimaging and electrophysiological studies of the effects of acute tryptophan depletion: a systematic review of the literature.Psychopharmacology · 2006Pooled it
- Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms.The international journal of neuropsychopharmacology · 2022Trial
- Cortico-limbic connectivity in MAOA-L carriers is vulnerable to acute tryptophan depletion.Human brain mapping · 2017Trial
- Improving response inhibition systems in frontotemporal dementia with citalopram.Brain : a journal of neurology · 2015Trial
- Serotonin 2A receptors, citalopram and tryptophan-depletion: a multimodal imaging study of their interactions during response inhibition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Punishment promotes response control deficits in obsessive-compulsive disorder: evidence from a motivational go/no-go task.Psychological medicine · 2013Trial
- Neurochemical enhancement of conscious error awareness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Trial
- Time series fMRI measures detect changes in pontine raphé following acute tryptophan depletion.Psychiatry research · 2011Trial
- Acute tryptophan depletion in healthy males attenuates phasic cardiac slowing but does not affect electro-cortical response to negative feedback.Psychopharmacology · 2008Trial
- Inhibitory control and academic achievement - a study of the relationship between Stroop Effect and university students' academic performance.BMC psychology · 2024Article
- Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- The Role of Tryptophan and Tyrosine in Executive Function and Reward Processing.International journal of tryptophan research : IJTR · 2020Review
- Neuroinflammation as a risk factor for attention deficit hyperactivity disorder.Pharmacology, biochemistry, and behavior · 2019Review
- Effects of acute tryptophan depletion on raphé functional connectivity in depression.Psychiatry research · 2015Article
- Response inhibition and interference control in obsessive-compulsive spectrum disorders.Frontiers in human neuroscience · 2014Review
- Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression.Journal of psychiatry & neuroscience : JPN · 2013Article
- Memory monitoring performance and PFC activity are associated with 5-HTTLPR genotype in older adults.Neuropsychologia · 2012Article
- Importance of reward and prefrontal circuitry in hunger and satiety: Prader-Willi syndrome vs simple obesity.International journal of obesity (2005) · 2012Article
- Differential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants.Psychopharmacology · 2011Article
- Disorder-specific dysfunctions in patients with attention-deficit/hyperactivity disorder compared to patients with obsessive-compulsive disorder during interference inhibition and attention allocation.Human brain mapping · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleSerotonin (5-HT) was implicated in both clinical and experimental studies in flexible, goal-directed behavior. However, the way in which 5-HT manipulations affect brain activation patterns underlying different subprocesses of cognitive flexibility remains largely unknown.
objectivesThe aim of this study was to investigate the effect of a transient lowering of 5-HT on brain activation during performance monitoring and response inhibition. MATERIALS AND
methodsWe used acute tryptophan depletion (ATD), a well-known method to reduce central 5-HT, to investigate the effect of a transient lowering of 5-HT on the blood-oxygen-level dependent (BOLD) response in an event-related functional MRI study. Thirteen healthy male volunteers performed a modified Go/NoGo task in a counterbalanced, placebo-controlled, within-subject design.
resultsATD significantly lowered plasma tryptophan but did not affect mood and cognitive performance. ATD decreased the BOLD response in the dorsomedial prefrontal cortex (BA 8) during performance monitoring. ATD did not affect the BOLD response during response inhibition.
conclusionsThis study provides more evidence for the suggested role of 5-HT in performance monitoring. Because ATD studies have revealed inconsistent effects of ATD on performance and on brain activation, it was suggested that gender and personality traits are important variables to take into account for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.