ArticlePLoS genetics2006
Epigenetic telomere protection by Drosophila DNA damage response pathways.
Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Developmental stage dominates cell-type identity and reveals a chromatin regulatory function for Rad50 in Drosophila.Nucleic acids research · 2026Article
- Genetic mechanisms of formation of radiation-induced instability of the genome and its transgenerational effects in the descendants of chronically irradiated individuals of Drosophila melanogaster.Radiation and environmental biophysics · 2020Article
- NBS1 interacts with HP1 to ensure genome integrity.Cell death & disease · 2019Article
- microRNAs selectively protect hub cells of the germline stem cell niche from apoptosis.The Journal of cell biology · 2018Article
- Article
- Recurrent Innovation at Genes Required for Telomere Integrity in Drosophila.Molecular biology and evolution · 2017Article
- The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres.PLoS genetics · 2015Article
- Protection of Drosophila chromosome ends through minimal telomere capping.Journal of cell science · 2015Article
- Drosophila as a Potential Model for Ocular Tumors.Ocular oncology and pathology · 2015Review
- Article
- Article
- A hypomorphic mutation reveals a stringent requirement for the ATM checkpoint protein in telomere protection during early cell division in Drosophila.G3 (Bethesda, Md.) · 2013Article
- Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human Telomeres.Frontiers in oncology · 2013Article
- Multiple pathways suppress telomere addition to DNA breaks in the Drosophila germline.Genetics · 2012Article
- A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint.Science signaling · 2011Article
- MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster.PloS one · 2011Article
- To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?Frontiers in bioscience (Landmark edition) · 2010Review
- HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner.The EMBO journal · 2010Article
- A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs.The EMBO journal · 2009Review
- Taming the tiger by the tail: modulation of DNA damage responses by telomeres.The EMBO journal · 2009Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as atm/tefu, mre11, or rad50 disrupt telomere protection and localization of the telomere-associated proteins HP1 and HOAP, suggesting that recognition of chromosome ends contributes to telomere protection. However, the partial telomere protection phenotype of these mutations limits the ability to test if they act in the epigenetic telomere protection mechanism. We examined the roles of the Drosophila atm and atr-atrip DNA damage response pathways and the nbs homolog in DNA damage responses and telomere protection. As in other organisms, the atm and atr-atrip pathways act in parallel to promote telomere protection. Cells lacking both pathways exhibit severe defects in telomere protection and fail to localize the protection protein HOAP to telomeres. Drosophila nbs is required for both atm- and atr-dependent DNA damage responses and acts in these pathways during DNA repair. The telomere fusion phenotype of nbs is consistent with defects in each of these activities. Cells defective in both the atm and atr pathways were used to examine if DNA damage response pathways regulate telomere protection without affecting telomere specific sequences. In these cells, chromosome fusion sites retain telomere-specific sequences, demonstrating that loss of these sequences is not responsible for loss of protection. Furthermore, terminally deleted chromosomes also fuse in these cells, directly implicating DNA damage response pathways in the epigenetic protection of telomeres. We propose that recognition of chromosome ends and recruitment of HP1 and HOAP by DNA damage response proteins is essential for the epigenetic protection of Drosophila telomeres. Given the conserved roles of DNA damage response proteins in telomere function, related mechanisms may act at the telomeres of other organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.