ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2006
Identifying genes in monoamine nuclei that may determine stress vulnerability and depressive behavior in Wistar-Kyoto rats.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Premotor projections from the locus coeruleus and periaqueductal grey are altered in two rat models with inborn differences in emotional behavior.Experimental brain research · 2024Article
- Anxiety-like Behavior and GABAAR/BDZ Binding Site Response to Progesterone Withdrawal in a Stress-Vulnerable Strain, the Wistar Kyoto Rats.International journal of molecular sciences · 2022Article
- Targeting opioid dysregulation in depression for the development of novel therapeutics.Pharmacology & therapeutics · 2019Review
- New directions for the treatment of depression: Targeting the photic regulation of arousal and mood (PRAM) pathway.Depression and anxiety · 2017Review
- Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression.Scientific reports · 2016Article
- Inflammatory Factors Mediate Vulnerability to a Social Stress-Induced Depressive-like Phenotype in Passive Coping Rats.Biological psychiatry · 2015Article
- Antidepressant-like effects of buprenorphine in rats are strain dependent.Behavioural brain research · 2015Article
- Sleep active cortical neurons expressing neuronal nitric oxide synthase are active after both acute sleep deprivation and chronic sleep restriction.Neuroscience · 2013Article
- Neuropeptide regulation of the locus coeruleus and opiate-induced plasticity of stress responses.Advances in pharmacology (San Diego, Calif.) · 2013Review
- Stress-induced epigenetic regulation of κ-opioid receptor gene involves transcription factor c-Myc.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Importance of stress receptor-mediated mechanisms in the amygdala on visceral pain perception in an intrinsically anxious rat.Neurogastroenterology and motility · 2012Article
- Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats.PloS one · 2012Article
- Stress-hyperresponsive WKY rats demonstrate depressed dorsal raphe neuronal excitability and dysregulated CRF-mediated responses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Central monoamine levels differ between rat strains used in studies of depressive behavior.Brain research · 2010Article
- Expression profiling of a genetic animal model of depression reveals novel molecular pathways underlying depressive-like behaviours.PloS one · 2010Article
- Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats.Psychopharmacology · 2010Article
- Gene expression studies in major depression.Current psychiatry reports · 2010Review
- Antidepressant-like effects of kappa-opioid receptor antagonists in Wistar Kyoto rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Presynaptic inhibition of diverse afferents to the locus ceruleus by kappa-opiate receptors: a novel mechanism for regulating the central norepinephrine system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Wistar-Kyoto (WKY) rat is stress sensitive and exhibits depressive-like behavior. The locus coeruleus (LC)-norepinephrine and dorsal raphe (DR)-serotonin systems mediate certain aspects of the stress response and have been implicated in depression. Microarray technology was used to identify gene expression differences in the LC and DR between WKY vs Sprague-Dawley (SD) rats that might account for the WKY phenotype. RNA was isolated from microdissected LC and DR, amplified, and hybridized to microarrays (1 array/subject, n = 4/group). Significance of microarray (SAM) analysis revealed increased expression of 66 genes in the LC and 19 genes in the DR and decreased expression of 33 genes in the DR of WKY rats. Hierarchical clustering identified differences in gene expression profiles of WKY vs SD rats that generally concurred with SAM. Notably, genes that encoded for enzymes involved in norepinephrine turnover, amino-acid receptors, and certain G-protein-coupled receptors were elevated in the LC of WKY rats. The DR of WKY rats showed decreased expression of genes encoding several potassium channels and neurofilament genes. The chromosomal locations of 15 genes that were differentially expressed in WKY rats were near loci identified as contributing to depressive-like behaviors in the rat. The specific genes revealed by the present analysis as being differentially expressed in WKY rats may contribute to their unique behavioral profile and suggest targets that confer susceptibility to stress-related psychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.