ArticleThe EMBO journal2006
Molecular basis for temperature sensing by an RNA thermometer.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed.
- RNA thermometers as temperature-dependent tools for enhanced recombinant protein production in precision fermentation.Microbial cell factories · 2026Article
- Mechanisms of thermoregulation inJournal of bacteriology · 2026Review
- Temperature-Dependent Recombinase-Based Genetic Circuits.International journal of molecular sciences · 2025Article
- Structural switching dynamically controls the doubly pseudoknotted Rous sarcoma virus-programmed ribosomal frameshifting element.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Robo-Therm, a pipeline to RNA thermometer discovery and validation.RNA (New York, N.Y.) · 2024Article
- Temperature-sensing riboceptors.RNA biology · 2024Article
- The plant noncoding transcriptome: a versatile environmental sensor.The EMBO journal · 2023Review
- Rock, scissors, paper: How RNA structure informs function.The Plant cell · 2023Article
- Insights into the temperature responses of Pseudomonas species in beneficial and pathogenic host interactions.Applied microbiology and biotechnology · 2022Review
- Upstream Flanking Sequence Assists Folding of an RNA Thermometer.Journal of molecular biology · 2022Article
- Response and regulatory mechanisms of heat resistance in pathogenic fungi.Applied microbiology and biotechnology · 2022Review
- Decreased thermal niche breadth as a trade-off of antibiotic resistance.The ISME journal · 2022Article
- The effect of mutation in the stem of the MicroROSE thermometer on its thermosensing ability: insights from molecular dynamics simulation studies.RSC advances · 2022Article
- 5'UTR sequences influence protein levels inFrontiers in microbiology · 2022Article
- RNA structure mediated thermoregulation: What can we learn from plants?Frontiers in plant science · 2022Review
- The gatekeeper of Yersinia type III secretion is under RNA thermometer control.PLoS pathogens · 2021Article
- The Role of RNA Secondary Structure in Regulation of Gene Expression in Bacteria.International journal of molecular sciences · 2021Review
- Exploiting RNA thermometer-driven molecular bioprocess control as a concept for heterologous rhamnolipid production.Scientific reports · 2021Article
- Regulation of OmpA Translation and Shigella dysenteriae Virulence by an RNA Thermometer.Infection and immunity · 2020Article
- Post-Transcriptional Mechanisms Respond Rapidly to Ecologically Relevant Thermal Fluctuations During Temperature-Dependent Sex Determination.Integrative organismal biology (Oxford, England) · 2020Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulatory RNA elements, like riboswitches, respond to intracellular signals by three-dimensional (3D) conformational changes. RNA thermometers employ a similar strategy to sense temperature changes in the cell and regulate the translational machinery. We present here the first 3D NMR structure of the functional domain of a highly conserved bacterial RNA thermometer containing the ribosome binding site that remains occluded at normal temperatures (30 degrees C). We identified a region adjacent to the Shine-Dalgarno sequence that has a network of weak hydrogen bonds within the RNA helix. With the onset of heat shock at 42 degrees C, destabilisation of the RNA structure initiates at this region and favours the release of the ribosome binding site and of the start codon. Deletion of a highly conserved G residue leads to the formation of a stable regular RNA helix that loses thermosensing ability. Our results indicate that RNA thermometers are able to sense temperature changes without the aid of accessory factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.